| URN | urn:agi-llid:3486 |
|---|---|
| Name | IGFBP3 |
| Description | insulin-like growth factor binding protein 3 |
| Connectivity | 497 |
| Notes | This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq] |
| Swiss-Prot Accession | P17936 |
|---|---|
| Q6ZSD0 | |
| Q71RC0 | |
| Q3UR87 | |
| Q6PE62 | |
| P47878 | |
| Q8BP94 | |
| P15473 |
| Unigene ID | Hs.450230 |
|---|---|
| Mm.29254 | |
| Rn.26369 |
| KEGG ID | hsa:3486 |
|---|---|
| mmu:16009 | |
| rno:24484 |
| Swiss-Prot ID | IBP3_HUMAN |
|---|---|
| IBP3_RAT | |
| Q3UR87_MOUSE | |
| Q6PE62_MOUSE |
| Cell Localization | Mitochondria |
|---|---|
| Extracellular |
| GO ID | 0031994 |
|---|---|
| 0046872 | |
| 0008160 | |
| 0001933 | |
| 0009968 | |
| 0014912 | |
| 0048662 | |
| 0043065 | |
| 0045663 | |
| 0001558 | |
| 0005576 | |
| 0016942 | |
| 0005634 | |
| 0019838 | |
| 0005520 | |
| 0001649 | |
| 0006468 | |
| 0005615 | |
| 0031995 | |
| 0005515 | |
| 0042568 | |
| 0042567 | |
| 0005625 |
| Pathway | VDR Targets |
|---|
| IPI ID | IPI00018305 |
|---|---|
| IPI00444386 | |
| IPI00435925 | |
| IPI00556155 | |
| IPI00754000 | |
| IPI00112485 | |
| IPI00209369 |
| Ariadne Ontology | IGFBP |
|---|---|
| Mitochondrial protein transport |
| Mouse chromosome position | 11 1.35 cM |
|---|
| GO Molecular Function | protein binding |
|---|---|
| metal ion binding | |
| growth factor binding | |
| insulin-like growth factor binding | |
| insulin-like growth factor I binding | |
| insulin-like growth factor II binding | |
| protein tyrosine phosphatase activator activity |
| Homologene ID | 500 |
|---|
| Hugo ID | 5472 |
|---|
| GO Cellular Component | extracellular region |
|---|---|
| soluble fraction | |
| nucleus | |
| extracellular space | |
| insulin-like growth factor binding protein complex | |
| insulin-like growth factor binary complex | |
| insulin-like growth factor ternary complex |
| MGI ID | 96438 |
|---|
| Human chromosome position | 7p13-p12 |
|---|
| GO Biological Process | negative regulation of signal transduction |
|---|---|
| negative regulation of smooth muscle cell migration | |
| negative regulation of smooth muscle cell proliferation | |
| negative regulation of protein amino acid phosphorylation | |
| positive regulation of apoptosis | |
| positive regulation of myoblast differentiation | |
| regulation of cell growth | |
| osteoblast differentiation | |
| protein amino acid phosphorylation |
| Rat chromosome position | 14q21 |
|---|
| Group | IGFBP |
|---|---|
| Mitochondrial protein transport | |
| extracellular region | |
| soluble fraction | |
| nucleus | |
| extracellular space | |
| insulin-like growth factor binding protein complex | |
| insulin-like growth factor binary complex | |
| insulin-like growth factor ternary complex | |
| protein binding | |
| metal ion binding | |
| growth factor binding | |
| insulin-like growth factor binding | |
| insulin-like growth factor I binding | |
| insulin-like growth factor II binding | |
| protein tyrosine phosphatase activator activity | |
| negative regulation of signal transduction | |
| negative regulation of smooth muscle cell migration | |
| negative regulation of smooth muscle cell proliferation | |
| negative regulation of protein amino acid phosphorylation | |
| positive regulation of apoptosis | |
| positive regulation of myoblast differentiation | |
| regulation of cell growth | |
| osteoblast differentiation | |
| protein amino acid phosphorylation |
| RGD ID | 2874 |
|---|
| LocusLink ID | 3486 |
|---|---|
| 16009 | |
| 24484 |
| Alias | IBP3 |
|---|---|
| BP-53 | |
| tcag7.703 | |
| insulin-like growth factor binding protein 3 | |
| binding protein 29 | |
| binding protein 53 | |
| IGF-binding protein 3 | |
| growth hormone-dependent binding protein | |
| acid stable subunit of the 140 K IGF complex | |
| IGFBP-3 | |
| IGgfbp3 | |
| AI649005 | |
| RP23-20C9.1 | |
| OTTMUSP00000005343 | |
| IGF-BP3 | |
| MGC156773 | |
| insulin-like growth factor-binding protein (IGF-BP3) | |
| IBP IIIs | |
| Igfbp3 | |
| IGF-binding protein III | |
| insulin-like growth factor binding protein III | |
| IBP-3 | |
| IBP III | |
| Igfbp3s |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 146732 |
|---|