| URN | urn:agi-llid:1555 |
|---|---|
| Name | CYP2B6 |
| Description | cytochrome P450, family 2, subfamily B, polypeptide 6 |
| Connectivity | 161 |
| Notes | This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize some xenobiotics, such as the anti-cancer drugs cyclophosphamide and ifosphamide. Transcript variants for this gene have been described; however, it has not been resolved whether these transcripts are in fact produced by this gene or by a closely related pseudogene, CYP2B7. Both the gene and the pseudogene are located in the middle of a CYP2A pseudogene found in a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. [provided by RefSeq] |
| Swiss-Prot Accession | P20813 |
|---|---|
| Q6NWU1 | |
| Q6NWU2 | |
| Q9UNX8 | |
| Q9WUD0 | |
| P12791 | |
| Q6LCL8 | |
| P04167 | |
| Q03738 | |
| Q63142 | |
| Q63143 |
| Unigene ID | Hs.1360 |
|---|---|
| Mm.218749 | |
| Rn.91353 |
| KEGG ID | hsa:1555 |
|---|---|
| mmu:13088 | |
| rno:361523 |
| EC Number | 1.14.14.1 |
|---|
| Swiss-Prot ID | CP2B6_HUMAN |
|---|---|
| Q9WUD0_MOUSE |
| Cell Localization | Plasma membrane |
|---|
| GO ID | 0070330 |
|---|---|
| 0009055 | |
| 0020037 | |
| 0046872 | |
| 0055114 | |
| 0005783 | |
| 0005789 | |
| 0016020 | |
| 0005792 | |
| 0005506 | |
| 0004497 | |
| 0016491 | |
| 0016712 | |
| 0008395 | |
| 0007568 | |
| 0017144 | |
| 0018933 | |
| 0051592 | |
| 0010038 | |
| 0014070 |
| Pathway | Toxicology Array |
|---|---|
| VDR Targets |
| IPI ID | IPI00025829 |
|---|---|
| IPI00310429 | |
| IPI00828864 | |
| IPI00264925 | |
| IPI00465739 | |
| IPI00193234 | |
| IPI00480585 | |
| IPI00766868 |
| Ariadne Ontology | Leukotriene synthesis |
|---|
| Mouse chromosome position | 7 6.5 cM |
|---|
| GO Molecular Function | electron carrier activity |
|---|---|
| metal ion binding | |
| iron ion binding | |
| heme binding | |
| oxidoreductase activity | |
| monooxygenase activity | |
| steroid hydroxylase activity | |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | |
| aromatase activity |
| Homologene ID | 73894 |
|---|
| Hugo ID | 2615 |
|---|
| GO Cellular Component | membrane |
|---|---|
| microsome | |
| endoplasmic reticulum membrane | |
| endoplasmic reticulum |
| MGI ID | 88598 |
|---|
| Human chromosome position | 19q13.2 |
|---|
| GO Biological Process | drug metabolic process |
|---|---|
| aging | |
| oxidation reduction | |
| nicotine metabolic process | |
| response to metal ion | |
| response to calcium ion | |
| response to organic cyclic substance |
| Rat chromosome position | 1q21 |
|---|
| Group | Leukotriene synthesis |
|---|---|
| membrane | |
| microsome | |
| endoplasmic reticulum membrane | |
| endoplasmic reticulum | |
| electron carrier activity | |
| metal ion binding | |
| iron ion binding | |
| heme binding | |
| oxidoreductase activity | |
| monooxygenase activity | |
| steroid hydroxylase activity | |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | |
| aromatase activity | |
| drug metabolic process | |
| aging | |
| oxidation reduction | |
| nicotine metabolic process | |
| response to metal ion | |
| response to calcium ion | |
| response to organic cyclic substance |
| RGD ID | 2467 |
|---|
| LocusLink ID | 1555 |
|---|---|
| 13088 | |
| 361523 |
| Alias | CPB6 |
|---|---|
| IIB1 | |
| P450 | |
| CYP2B | |
| CYPIIB6 | |
| cytochrome P450, family 2, subfamily B, polypeptide 6 | |
| cytochrome P450, subfamily IIB (phenobarbital-inducible), polypeptide 6 | |
| p16 | |
| Cyp2b20 | |
| cytochrome P450, family 2, subfamily b, polypeptide 10 | |
| cytochrome P450, 2b20 | |
| phenobarbitol inducible, type b | |
| cytochrome P450, 2b10, phenobarbitol inducible, type b | |
| cytochrome P450, family 2, subfamily b, polypeptide 20 | |
| Cype | |
| cytochrome P450, family 2, subfamily b, polypeptide 2 | |
| cytochrome P-450e-M | |
| cytochrome P-450b type e | |
| Cytochrome P450, subfamily IIB (phenobarbital-inducible)(b, e) | |
| cytochrome P450, 2b6, phenobarbitol inducible, type b | |
| BROD | |
| 7-Benzyloxyresorufin O-debenzylase | |
| phenobarbitol inducible, type a | |
| Cyp2b10 | |
| Cyp2b13 | |
| Cyp2b15 | |
| Cyp2b6 | |
| Cyp2b9 | |
| Cytochrome P450 2B6 | |
| cytochrome P450, 2b13, phenobarbitol inducible, type c | |
| cytochrome P450, 2b9, phenobarbitol inducible, type a | |
| cytochrome P450, family 2, subfamily b, polypeptide 13 | |
| cytochrome P450, family 2, subfamily b, polypeptide 19 | |
| cytochrome P450, family 2, subfamily b, polypeptide 9 | |
| P450 IIB1 | |
| phenobarbital inducible, type c | |
| debenzylase | |
| debenzylases | |
| cytochrome P450, subfamily IIB (phenobarbital-inducible), polypeptide VI | |
| Cytochrome P450 2B3 | |
| cytochrome P450 2B15 | |
| Cyp2b19 | |
| IIB I | |
| P450 2B I | |
| P450 IIB I | |
| Cyp2b2 | |
| cytochrome p-450b | |
| cytochrome p450, subfamily iib | |
| cytochrome p450, family 2, subfamily b, polypeptide II | |
| LOC361523 | |
| cytochrome P-450e-M mRNA | |
| Cytochrome P450 subfamily IIB (phenobarbital-inducible)(b e) | |
| Cytochrome P450 2B1 | |
| LOC82059 | |
| P450 2B1 | |
| P450 2B6 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 123930 |
|---|