| URN | urn:agi-llid:5744 |
|---|---|
| Name | PTHLH |
| Description | parathyroid hormone-like hormone |
| Connectivity | 634 |
| Notes | The protein encoded by this gene is a member of the parathyroid hormone family. This hormone regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. This hormone is involved in lactation possibly by regulating the mobilization and transfer of calcium to the milk. The receptor of this hormone, PTHR1, is responsible for most cases of humoral hypercalcemia of malignancy. Four alternatively spliced transcript variants encoding two distinct isoforms have been observed. There is also evidence for alternative translation initiation from non-AUG (CUG and GUG) start sites, in-frame and downstream of the initiator AUG codon, to give rise to nuclear forms of this hormone. [provided by RefSeq] |
| Swiss-Prot Accession | P12272 |
|---|---|
| Q53XY9 | |
| Q6FH74 | |
| Q540C1 | |
| Q924X4 | |
| P22858 | |
| Q811S6 | |
| P13085 |
| Unigene ID | Hs.591159 |
|---|---|
| Mm.28440 | |
| Rn.9750 |
| KEGG ID | hsa:5744 |
|---|---|
| mmu:19227 | |
| rno:24695 |
| Swiss-Prot ID | PTHR_HUMAN |
|---|---|
| PTHR_RAT | |
| Q53XY9_HUMAN | |
| Q6FH74_HUMAN | |
| Q540C1_MOUSE | |
| Q924X4_MOUSE |
| Cell Localization | Extracellular |
|---|
| GO ID | 0005509 |
|---|---|
| 0005179 | |
| 0007189 | |
| 0048286 | |
| 0046058 | |
| 0007267 | |
| 0001958 | |
| 0008544 | |
| 0030855 | |
| 0007565 | |
| 0007595 | |
| 0008285 | |
| 0032331 | |
| 0002076 | |
| 0008284 | |
| 0001501 | |
| 0043129 | |
| 0005737 | |
| 0005576 | |
| 0005615 | |
| 0005622 | |
| 0005634 | |
| 0030282 | |
| 0007492 | |
| 0043433 | |
| 0030819 | |
| 0016485 | |
| 0010468 | |
| 0005575 |
| Pathway | VDR Targets |
|---|
| IPI ID | IPI00414875 |
|---|---|
| IPI00221080 | |
| IPI00221081 | |
| IPI00871431 | |
| IPI00796926 | |
| IPI00797573 | |
| IPI00795530 | |
| IPI00132544 | |
| IPI00850394 | |
| IPI00197554 |
| Ariadne Ontology | Neuromodulator |
|---|
| Mouse chromosome position | 6 74.0 cM |
|---|
| GO Molecular Function | calcium ion binding |
|---|---|
| hormone activity |
| Homologene ID | 2113 |
|---|
| Hugo ID | 9607 |
|---|
| GO Cellular Component | cellular_component |
|---|---|
| extracellular region | |
| intracellular | |
| cytoplasm | |
| nucleus | |
| extracellular space |
| MGI ID | 97800 |
|---|
| Human chromosome position | 12p12.1-p11.2 |
|---|
| GO Biological Process | negative regulation of cell proliferation |
|---|---|
| negative regulation of chondrocyte differentiation | |
| positive regulation of cell proliferation | |
| positive regulation of cAMP biosynthetic process | |
| activation of adenylate cyclase activity by G-protein signaling pathway | |
| negative regulation of transcription factor activity | |
| regulation of gene expression | |
| surfactant homeostasis | |
| cell-cell signaling | |
| osteoblast development | |
| epithelial cell differentiation | |
| cAMP metabolic process | |
| alveolus development | |
| endochondral ossification | |
| bone mineralization | |
| lactation | |
| endoderm development | |
| epidermis development | |
| skeletal system development | |
| protein processing | |
| female pregnancy |
| Rat chromosome position | 4q44 |
|---|
| Group | Neuromodulator |
|---|---|
| cellular_component | |
| extracellular region | |
| intracellular | |
| cytoplasm | |
| nucleus | |
| extracellular space | |
| calcium ion binding | |
| hormone activity | |
| negative regulation of cell proliferation | |
| negative regulation of chondrocyte differentiation | |
| positive regulation of cell proliferation | |
| positive regulation of cAMP biosynthetic process | |
| activation of adenylate cyclase activity by G-protein signaling pathway | |
| negative regulation of transcription factor activity | |
| regulation of gene expression | |
| surfactant homeostasis | |
| cell-cell signaling | |
| osteoblast development | |
| epithelial cell differentiation | |
| cAMP metabolic process | |
| alveolus development | |
| endochondral ossification | |
| bone mineralization | |
| lactation | |
| endoderm development | |
| epidermis development | |
| skeletal system development | |
| protein processing | |
| female pregnancy |
| RGD ID | 3441 |
|---|
| LocusLink ID | 5744 |
|---|---|
| 19227 | |
| 24695 |
| Alias | HHM |
|---|---|
| PLP | |
| PTHR | |
| PTHRP | |
| MGC14611 | |
| parathyroid hormone-like hormone | |
| osteostatin | |
| PTH-related protein | |
| parathyroid-like protein | |
| parathyroid hormone-like protein | |
| humoral hypercalcemia of malignancy | |
| parathyroid hormone-related protein | |
| parathyroid hormone-like related protein | |
| PTH-like | |
| RP24-249N9.4 | |
| parathyroid hormone-like peptide | |
| OTTMUSP00000031937 | |
| PTH-related peptide | |
| parathyroid hormone-related peptide | |
| parathyroid-like peptide | |
| Parathyroid hormone-related protein precursor | |
| PTHLH | |
| PTH-related | |
| PTH-rP | |
| humoral hypercalcemia of malignancy gene | |
| humoral hypercalcemia of malignancy protein |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 168470 |
|---|