| URN | urn:agi-llid:4803 |
|---|---|
| Name | NGF |
| Description | nerve growth factor, beta |
| Connectivity | 1603 |
| Notes | Circulating levels in Behcet disease are not different from normal values. Circulating levels in Behcet disease are not different from normal values. Data suggest that activation of bronchial eosinophils by neurotrophins (nerve growth factor, brain-derived neurotrophic factor, neurotrophins-3 and -4) might play a role in the regulation of eosinophilic inflammation in allergic asthma. Interleukin-10 and nerve growth factor have reciprocal upregulatory effects on intestinal epithelial cells. Monocytes, produce, store and release NGF, brain-derived neurotrophic factor and neurotrophin 3. NGF is expressed in human pancreatic beta cells and modulates insulin secretion through a paracrine/autocrine loop, similar to the one observed in cultured rat beta cells. NGF is indeed involved in growth initiation of human primordial follicles. NGF might have a crucial role in the auditory pathway, promoting the survival and preventing the degeneration of sensorineural cells. NGF modulates cytokine mRNA expression in immune cells. (NGF). On immunologic stimuli, human eosinophils secrete nerve growth factor that promotes elongation of neurites. Phenotypic knockout of nerve growth factor (NGF) activity in transgenic anti-NGF mice (AD11 mice) results in a progressive neurodegenerative phenotype. Results support the involvement of NGF, BDNF, leptin, and mast cells in human coronary atherosclerosis and metabolic syndrome, implying neuroimmune and adipoimmune pathways in the pathobiology of these cardiovascular disorders. The gene expression of this protein was studied in the developing human tooth. This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis. Zinc(II) in native beta-NGF plays an important role in the structure and the biological activity of the protein. Acts as a co-receptor and molecular switch governing the p75NTR-mediated pro-apoptotic signal induced by proNGF. Correlation between the activity of systemic lupus erythematosus and the levels of NGF in serum. Determined the 2.4 A crystal structure of NGF complexed with the extracellular domain of p75; the complex is composed of an NGF homodimer asymmetrically bound to a single p75. Expression of NGF and its receptors, TrkA and p75NTR, in hepatocellular carcinomas (HCC); NGF and its receptors are thought to have a role in cellular interactions involving HCC cells, hepatic stellate cells, arterial cells and nerve cells in HCC tissues. Histamine may enhance nerve growth factor production by inducing c-Fos expression in keratinocytes. Mutation causes loss of pain perception. P62 regulates nerve growth factor-induced NF-kappaB activation by influencing TRAF6 polyubiquitination. Pro-NGF purified from AD human brains can induce apoptosis in neuronal cell cultures through its interaction with the p75NTR receptor. |
| KEGG pathway | Apoptosis |
|---|---|
| MAPK signaling pathway |
| Swiss-Prot Accession | P01138 |
|---|---|
| P01139 | |
| Q6LDU8 | |
| P25427 | |
| Q6FHA0 |
| Unigene ID | Hs.2561 |
|---|---|
| Mm.1259 | |
| Rn.22168 |
| KEGG ID | hsa:4803 |
|---|---|
| mmu:18049 | |
| rno:310738 |
| Swiss-Prot ID | NGF_HUMAN |
|---|---|
| NGF_MOUSE | |
| Q6LDU8_MOUSE |
| Cell Localization | Extracellular |
|---|
| GO ID | 0008083 |
|---|---|
| 0005163 | |
| 0005057 | |
| 0007265 | |
| 0032455 | |
| 0007422 | |
| 0045773 | |
| 0045664 | |
| 0046928 | |
| 0019233 | |
| 0007169 | |
| 0005796 | |
| 0005768 | |
| 0005576 | |
| 0005102 | |
| 0043524 | |
| 0005788 | |
| 0003674 | |
| 0008344 | |
| 0006954 | |
| 0007613 | |
| 0031175 | |
| 0030307 | |
| 0008284 | |
| 0042493 | |
| 0051602 | |
| 0051384 | |
| 0032496 | |
| 0009612 | |
| 0014070 | |
| 0010033 | |
| 0043434 | |
| 0009314 | |
| 0005615 | |
| 0007267 | |
| 0007275 | |
| 0004871 |
| Pathway | NTRK -> AP-1/CREB/ELK-SRF/MYC/SMAD3/TP53 signaling |
|---|---|
| NTRK -> FOXO/MYCN signaling | |
| NGFR -> AP-1/CEBPB/CREB/ELK-SRF/TP53 signaling | |
| NGFR -> MEF signaling | |
| NGFR -> NF-kB signaling | |
| Donna Regulators | |
| VDR Targets |
| IPI ID | IPI00000076 |
|---|---|
| IPI00882237 | |
| IPI00336602 | |
| IPI00764219 | |
| IPI00368881 |
| Ariadne Ontology | NGF family |
|---|
| Mouse chromosome position | 3 48.5 cM |
|---|
| GO Molecular Function | molecular_function |
|---|---|
| receptor binding | |
| growth factor activity | |
| nerve growth factor receptor binding | |
| receptor signaling protein activity |
| Homologene ID | 1876 |
|---|
| Hugo ID | 7808 |
|---|
| GO Cellular Component | extracellular region |
|---|---|
| endosome | |
| Golgi lumen | |
| endoplasmic reticulum lumen | |
| extracellular space |
| MGI ID | 97321 |
|---|
| Human chromosome position | 1p13.1 |
|---|
| GO Biological Process | negative regulation of neuron apoptosis |
|---|---|
| positive regulation of cell proliferation | |
| positive regulation of cell growth | |
| positive regulation of axon extension | |
| regulation of neurotransmitter secretion | |
| regulation of neuron differentiation | |
| transmembrane receptor protein tyrosine kinase signaling pathway | |
| Ras protein signal transduction | |
| nerve growth factor processing | |
| neuron projection development | |
| peripheral nervous system development | |
| response to lipopolysaccharide | |
| adult locomotory behavior | |
| memory | |
| sensory perception of pain | |
| response to electrical stimulus | |
| response to mechanical stimulus | |
| response to radiation | |
| response to drug | |
| response to organic substance | |
| response to peptide hormone stimulus | |
| response to glucocorticoid stimulus | |
| response to organic cyclic substance | |
| inflammatory response |
| Rat chromosome position | 2q34 |
|---|
| Group | NGF family |
|---|---|
| extracellular region | |
| endosome | |
| Golgi lumen | |
| endoplasmic reticulum lumen | |
| extracellular space | |
| molecular_function | |
| receptor binding | |
| growth factor activity | |
| nerve growth factor receptor binding | |
| receptor signaling protein activity | |
| negative regulation of neuron apoptosis | |
| positive regulation of cell proliferation | |
| positive regulation of cell growth | |
| positive regulation of axon extension | |
| regulation of neurotransmitter secretion | |
| regulation of neuron differentiation | |
| transmembrane receptor protein tyrosine kinase signaling pathway | |
| Ras protein signal transduction | |
| nerve growth factor processing | |
| neuron projection development | |
| peripheral nervous system development | |
| response to lipopolysaccharide | |
| adult locomotory behavior | |
| memory | |
| sensory perception of pain | |
| response to electrical stimulus | |
| response to mechanical stimulus | |
| response to radiation | |
| response to drug | |
| response to organic substance | |
| response to peptide hormone stimulus | |
| response to glucocorticoid stimulus | |
| response to organic cyclic substance | |
| inflammatory response |
| RGD ID | 1598328 |
|---|---|
| 3174 |
| LocusLink ID | 4803 |
|---|---|
| 18049 | |
| 310738 | |
| 24593 |
| Alias | NGFB |
|---|---|
| HSAN5 | |
| Beta-NGF | |
| MGC161426 | |
| MGC161428 | |
| nerve growth factor, beta polypeptide | |
| OTTHUMP00000013653 | |
| beta-nerve growth factor | |
| nerve growth factor, beta subunit | |
| nerve growth factor, beta | |
| nerve growth factor (beta polypeptide) | |
| NGF | |
| Nerve growth factor | |
| NGF beta | |
| NGF_HUMAN | |
| Beta-nerve growth factor precursor | |
| nerve growth factor, beta (mapped) |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 162030 |
|---|---|
| 608654 |