| URN | urn:agi-llid:1027 |
|---|---|
| Name | CDKN1B |
| Description | cyclin-dependent kinase inhibitor 1B (p27, Kip1) |
| Connectivity | 741 |
| Notes | This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. |
| Swiss-Prot Accession | P46527 |
|---|---|
| Q6I9V6 | |
| O43806 | |
| Q708J1 | |
| Q96TE0 | |
| Q9NYG6 | |
| Q9UH60 | |
| P46414 | |
| Q8BG74 | |
| Q3TEK5 | |
| Q3U4E9 | |
| Q4FJM2 | |
| O08769 | |
| O35792 | |
| Q812C0 | |
| Q9QXH0 |
| Unigene ID | Hs.238990 |
|---|---|
| Mm.2958 | |
| Rn.29897 |
| KEGG ID | hsa:1027 |
|---|---|
| mmu:12576 | |
| rno:83571 |
| Swiss-Prot ID | CDN1B_HUMAN |
|---|---|
| CDN1B_MOUSE | |
| Q6I9V6_HUMAN | |
| O08769_RAT | |
| Q8BG74_MOUSE |
| Cell Localization | Cytoplasm |
|---|
| GO ID | 0004861 |
|---|---|
| 0005515 | |
| 0004860 | |
| 0005072 | |
| 0000082 | |
| 0048102 | |
| 0007049 | |
| 0007050 | |
| 0006917 | |
| 0030308 | |
| 0008285 | |
| 0042326 | |
| 0000079 | |
| 0005737 | |
| 0005829 | |
| 0005634 | |
| 0048839 | |
| 0051271 | |
| 0045736 | |
| 0050680 | |
| 0008284 | |
| 0031116 | |
| 0006813 | |
| 0007605 | |
| 0016301 | |
| 0032403 | |
| 0008219 | |
| 0043200 | |
| 0046686 | |
| 0042493 | |
| 0032355 | |
| 0009749 | |
| 0001666 | |
| 0014070 | |
| 0043434 | |
| 0006950 |
| Pathway | BCL6 |
|---|---|
| PPARbeta BCL6 Targets | |
| VDR Targets |
| IPI ID | IPI00006991 |
|---|---|
| IPI00852705 | |
| IPI00853130 | |
| IPI00133537 | |
| IPI00653050 | |
| IPI00307952 | |
| IPI00324784 |
| Ariadne Ontology | Tumor suppressors |
|---|---|
| CDKN |
| Mouse chromosome position | 6 62.0 cM |
|---|
| GO Molecular Function | protein binding |
|---|---|
| protein complex binding | |
| kinase activity | |
| protein kinase inhibitor activity | |
| cyclin-dependent protein kinase inhibitor activity | |
| transforming growth factor beta receptor, cytoplasmic mediator activity |
| Homologene ID | 2999 |
|---|
| Hugo ID | 1785 |
|---|
| GO Cellular Component | cytoplasm |
|---|---|
| cytosol | |
| nucleus |
| MGI ID | 104565 |
|---|
| Human chromosome position | 12p13.1-p12 |
|---|
| GO Biological Process | positive regulation of microtubule polymerization |
|---|---|
| negative regulation of cell motion | |
| negative regulation of cell proliferation | |
| negative regulation of cell growth | |
| negative regulation of cyclin-dependent protein kinase activity | |
| negative regulation of epithelial cell proliferation | |
| negative regulation of phosphorylation | |
| positive regulation of cell proliferation | |
| induction of apoptosis | |
| regulation of cyclin-dependent protein kinase activity | |
| cell death | |
| cell cycle | |
| cell cycle arrest | |
| G1-S transition of mitotic cell cycle | |
| autophagic cell death | |
| inner ear development | |
| potassium ion transport | |
| sensory perception of sound | |
| response to stress | |
| response to drug | |
| response to amino acid stimulus | |
| response to peptide hormone stimulus | |
| response to estradiol stimulus | |
| response to cadmium ion | |
| response to organic cyclic substance | |
| response to glucose stimulus | |
| response to hypoxia |
| Rat chromosome position | 4q43 |
|---|
| Group | Tumor suppressors |
|---|---|
| CDKN | |
| cytoplasm | |
| cytosol | |
| nucleus | |
| protein binding | |
| protein complex binding | |
| kinase activity | |
| protein kinase inhibitor activity | |
| cyclin-dependent protein kinase inhibitor activity | |
| transforming growth factor beta receptor, cytoplasmic mediator activity | |
| positive regulation of microtubule polymerization | |
| negative regulation of cell motion | |
| negative regulation of cell proliferation | |
| negative regulation of cell growth | |
| negative regulation of cyclin-dependent protein kinase activity | |
| negative regulation of epithelial cell proliferation | |
| negative regulation of phosphorylation | |
| positive regulation of cell proliferation | |
| induction of apoptosis | |
| regulation of cyclin-dependent protein kinase activity | |
| cell death | |
| cell cycle | |
| cell cycle arrest | |
| G1-S transition of mitotic cell cycle | |
| autophagic cell death | |
| inner ear development | |
| potassium ion transport | |
| sensory perception of sound | |
| response to stress | |
| response to drug | |
| response to amino acid stimulus | |
| response to peptide hormone stimulus | |
| response to estradiol stimulus | |
| response to cadmium ion | |
| response to organic cyclic substance | |
| response to glucose stimulus | |
| response to hypoxia |
| RGD ID | 69062 |
|---|
| LocusLink ID | 1027 |
|---|---|
| 12576 | |
| 83571 |
| Alias | KIP1 |
|---|---|
| MEN4 | |
| CDKN4 | |
| MEN1B | |
| P27KIP1 | |
| cyclin-dependent kinase inhibitor 1B | |
| p27 | |
| AA408329 | |
| AI843786 | |
| OTTMUSP00000023376 | |
| OTTMUSP00000023377 | |
| Cdki1b | |
| cyclin-dependent kinase inhibitor 1B (p27, kip1) | |
| cyclin-dependent kinase inhibitor p27 | |
| cyclin-dependent kinase inhibitor p27/Kip1 | |
| Cyclin-dependent kinase inhibitor 1B (p27 Kip1) | |
| Cyclin-dependent kinase inhibitor 1B (p27, Kip1) | |
| CDKN1B | |
| Cyclin-dependent kinase inhibitor P27 | |
| KIP I | |
| p27Kip I | |
| cyclin-dependent kinase inhibitor 1B (P27) | |
| expressed sequence AI843786 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 600778 |
|---|---|
| 610755 |