| URN | urn:agi-llid:3381 |
|---|---|
| Name | IBSP |
| Description | integrin-binding sialoprotein |
| Connectivity | 144 |
| Notes | The protein encoded by this gene is a major structural protein of the bone matrix. It constitutes approximately 12% of the noncollagenous proteins in human bone and is synthesized by skeletal-associated cell types, including hypertrophic chondrocytes, osteoblasts, osteocytes, and osteoclasts. The only extraskeletal site of its synthesis is the trophoblast. This protein binds to calcium and hydroxyapatite via its acidic amino acid clusters, and mediates cell attachment through an RGD sequence that recognizes the vitronectin receptor. [provided by RefSeq] |
| Swiss-Prot Accession | P21815 |
|---|---|
| Q80VR6 | |
| Q3TRM5 | |
| Q61711 | |
| A0JPM6 | |
| P13839 | |
| Q3HLN4 |
| Unigene ID | Hs.518726 |
|---|---|
| Mm.4987 | |
| Rn.9721 |
| KEGG ID | hsa:3381 |
|---|---|
| mmu:15891 | |
| rno:24477 |
| Swiss-Prot ID | Q80VR6_MOUSE |
|---|---|
| SIAL_HUMAN | |
| A0JPM6_RAT |
| Cell Localization | Extracellular |
|---|
| GO ID | 0005515 |
|---|---|
| 0007155 | |
| 0001503 | |
| 0005576 | |
| 0030198 | |
| 0007229 | |
| 0005615 | |
| 0031988 | |
| 0005578 |
| Pathway | VDR Targets |
|---|
| IPI ID | IPI00294662 |
|---|---|
| IPI00322881 | |
| IPI00749962 | |
| IPI00205448 | |
| IPI00876575 |
| Ariadne Ontology | Extracellular matrix polymerization |
|---|
| Mouse chromosome position | 5 56.0 cM |
|---|
| GO Molecular Function | protein binding |
|---|
| Homologene ID | 3644 |
|---|
| Hugo ID | 5341 |
|---|
| GO Cellular Component | extracellular region |
|---|---|
| extracellular space | |
| proteinaceous extracellular matrix | |
| membrane-bounded vesicle |
| MGI ID | 96389 |
|---|
| Human chromosome position | 4q21-q25 |
|---|
| GO Biological Process | cell adhesion |
|---|---|
| integrin-mediated signaling pathway | |
| extracellular matrix organization | |
| ossification |
| Rat chromosome position | 14p22 |
|---|
| Group | Extracellular matrix polymerization |
|---|---|
| extracellular region | |
| extracellular space | |
| proteinaceous extracellular matrix | |
| membrane-bounded vesicle | |
| protein binding | |
| cell adhesion | |
| integrin-mediated signaling pathway | |
| extracellular matrix organization | |
| ossification |
| RGD ID | 2855 |
|---|
| LocusLink ID | 3381 |
|---|---|
| 15891 | |
| 24477 |
| Alias | BSP |
|---|---|
| BNSP | |
| SP-II | |
| BSP-II | |
| integrin-binding sialoprotein | |
| bone sialoprotein II | |
| Bsp2 | |
| integrin binding sialoprotein | |
| OTTMUSP00000023751 | |
| MGC156673 | |
| bone sialoprotein | |
| Integrin-binding sialoprotein (bone sialoprotein II) | |
| bone sialoprotein II, bone sialoprotein | |
| Ibsp | |
| integrin-binding sialoprotein (bone sialoprotein, bone sialoprotein II) | |
| Cell-binding sialoprotein | |
| Bone sialoprotein II precursor | |
| bone sialic protein |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 147563 |
|---|