| URN | urn:agi-llid:597 |
|---|---|
| Name | BCL2A1 |
| Description | BCL2-related protein A1 |
| Connectivity | 45 |
| Notes | This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and is up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] |
| Swiss-Prot Accession | Q86W13 |
|---|---|
| Q16548 | |
| Q6FH19 | |
| Q6FGZ4 | |
| Q07440 | |
| Q4FK02 | |
| Q8K164 | |
| O55177 | |
| Q497M6 | |
| Q9ESY3 | |
| O55179 | |
| Q3TN22 | |
| Q925A9 |
| Unigene ID | Hs.227817 |
|---|---|
| Mm.196770 | |
| Mm.425593 | |
| Mm.378888 | |
| Rn.19770 |
| KEGG ID | hsa:597 |
|---|---|
| mmu:12044 | |
| mmu:12045 | |
| mmu:12047 | |
| rno:170929 |
| Swiss-Prot ID | B2LA1_HUMAN |
|---|---|
| B2LA1_MOUSE | |
| Q6FH19_HUMAN | |
| Q86W13_HUMAN | |
| O55177_MOUSE | |
| O55179_MOUSE | |
| Q497M6_MOUSE | |
| Q925A9_RAT |
| Cell Localization | Cytoplasm |
|---|
| GO ID | 0005515 |
|---|---|
| 0006916 | |
| 0042981 | |
| 0005737 | |
| 0005622 | |
| 0001782 | |
| 0006915 | |
| 0043066 | |
| 0043027 | |
| 0030217 | |
| 0050852 | |
| 0043154 | |
| 0005575 |
| Pathway | Apoptosis |
|---|---|
| VDR Targets |
| IPI ID | IPI00002881 |
|---|---|
| IPI00384353 | |
| IPI00116671 | |
| IPI00116013 | |
| IPI00116019 | |
| IPI00915104 | |
| IPI00877252 | |
| IPI00205444 |
| Ariadne Ontology | Bcl |
|---|
| Mouse chromosome position | 9 50.0 cM |
|---|---|
| 9 E3.1 |
| GO Molecular Function | protein binding |
|---|---|
| caspase inhibitor activity |
| Hugo ID | 991 |
|---|
| GO Cellular Component | cellular_component |
|---|---|
| intracellular | |
| cytoplasm |
| MGI ID | 102687 |
|---|---|
| 1278326 | |
| 1278325 |
| Human chromosome position | 15q24.3 |
|---|
| GO Biological Process | negative regulation of apoptosis |
|---|---|
| anti-apoptosis | |
| T cell receptor signaling pathway | |
| regulation of apoptosis | |
| negative regulation of caspase activity | |
| B cell homeostasis | |
| T cell differentiation | |
| apoptosis |
| Rat chromosome position | 8q31 |
|---|
| Group | Bcl |
|---|---|
| cellular_component | |
| intracellular | |
| cytoplasm | |
| protein binding | |
| caspase inhibitor activity | |
| negative regulation of apoptosis | |
| anti-apoptosis | |
| T cell receptor signaling pathway | |
| regulation of apoptosis | |
| negative regulation of caspase activity | |
| B cell homeostasis | |
| T cell differentiation | |
| apoptosis |
| RGD ID | 620621 |
|---|
| LocusLink ID | 597 |
|---|---|
| 12044 | |
| 12045 | |
| 12047 | |
| 170929 |
| Alias | GRS |
|---|---|
| BFL1 | |
| ACC-1 | |
| ACC-2 | |
| HBPA1 | |
| BCL2L5 | |
| BCL2-related protein A1 | |
| hematopoietic BCL2-related protein A1 | |
| A1 | |
| Bfl-1 | |
| Bcl2a1 | |
| BB218357 | |
| B-cell leukemia/lymphoma 2 related protein A1a | |
| A1-b | |
| B-cell leukemia/lymphoma 2 related protein A1b | |
| anti-apoptotic protein A1-b | |
| A1-d | |
| B-cell leukemia/lymphoma 2 related protein A1d | |
| B-cell leukemia/lymphoma 2 related protein A1 | |
| BFL-1 protein | |
| B-cell leukemia/lymphoma 2 related protein A1c | |
| Bcl2a1c | |
| Hemopoietic-specific early response protein | |
| Bcl2a1d | |
| HBPA I | |
| BCL2A I | |
| Bcl2a1a | |
| Bcl2a1b | |
| A(1)C | |
| a1-c | |
| A1c | |
| A-1C |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 601056 |
|---|