| URN | urn:agi-llid:2253 |
|---|---|
| Name | FGF8 |
| Description | fibroblast growth factor 8 (androgen-induced) |
| Connectivity | 245 |
| Notes | The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is known to be a factor that supports androgen and anchorage independent growth of mammary tumor cells. Overexpression of this gene has been shown to increase tumor growth and angiogensis. The adult expression of this gene is restricted to testes and ovaries. Temporal and spatial pattern of this gene expression suggests its function as an embryonic epithelial factor. Studies of the mouse and chick homologs revealed roles in midbrain and limb development, organogenesis, embryo gastrulation and left-right axis determination. The alternative splicing of this gene results in four transcript variants. [provided by RefSeq] |
| Swiss-Prot Accession | P55075 |
|---|---|
| A1A514 | |
| P37237 | |
| Q3V279 | |
| Q60757 | |
| Q80ZL6 | |
| Q76LI5 |
| Unigene ID | Hs.57710 |
|---|---|
| Mm.4012 | |
| Rn.73565 |
| KEGG ID | rno:29349 |
|---|
| Swiss-Prot ID | FGF8_HUMAN |
|---|---|
| FGF8_MOUSE | |
| A1A514_HUMAN | |
| Q76LI5_RAT |
| Cell Localization | Extracellular |
|---|
| GO ID | 0008083 |
|---|---|
| 0009653 | |
| 0008283 | |
| 0008543 | |
| 0007369 | |
| 0007275 | |
| 0007165 | |
| 0005576 | |
| 0000165 | |
| 0006915 | |
| 0001974 | |
| 0045165 | |
| 0021846 | |
| 0007368 | |
| 0009792 | |
| 0035050 | |
| 0035116 | |
| 0021798 | |
| 0048853 | |
| 0048699 | |
| 0007507 | |
| 0001947 | |
| 0003007 | |
| 0001759 | |
| 0042472 | |
| 0001822 | |
| 0035108 | |
| 0030324 | |
| 0060425 | |
| 0030539 | |
| 0043066 | |
| 0043524 | |
| 0001839 | |
| 0021543 | |
| 0001569 | |
| 0008284 | |
| 0010628 | |
| 0045840 | |
| 0007435 | |
| 0021544 | |
| 0021537 | |
| 0001658 | |
| 0042056 | |
| 0021954 | |
| 0033563 | |
| 0021884 | |
| 0008045 | |
| 0006979 | |
| 0009897 |
| Pathway | FGFR3 -> STAT signaling |
|---|---|
| FGFR -> RUNX2 signaling | |
| VDR Targets |
| IPI ID | IPI00219933 |
|---|---|
| IPI00183471 | |
| IPI00218332 | |
| IPI00218333 | |
| IPI00125192 | |
| IPI00230745 | |
| IPI00230746 | |
| IPI00458786 | |
| IPI00404012 | |
| IPI00857425 | |
| IPI00830192 | |
| IPI00206639 | |
| IPI00387900 |
| Ariadne Ontology | GF |
|---|
| Mouse chromosome position | 19 45.0 cM |
|---|
| GO Molecular Function | chemoattractant activity |
|---|---|
| growth factor activity |
| Homologene ID | 7715 |
|---|
| Hugo ID | 3686 |
|---|
| GO Cellular Component | extracellular region |
|---|---|
| external side of plasma membrane |
| MGI ID | 99604 |
|---|
| Human chromosome position | 10q24 |
|---|
| GO Biological Process | patterning of blood vessels |
|---|---|
| induction of an organ | |
| negative regulation of apoptosis | |
| negative regulation of neuron apoptosis | |
| positive regulation of cell proliferation | |
| positive regulation of mitosis | |
| positive regulation of gene expression | |
| signal transduction | |
| fibroblast growth factor receptor signaling pathway | |
| MAPKKK cascade | |
| cell proliferation | |
| apoptosis | |
| dorsal-ventral axon guidance | |
| motor axon guidance | |
| cell proliferation in forebrain | |
| cell fate commitment | |
| generation of neurons | |
| forebrain neuron development | |
| central nervous system neuron development | |
| multicellular organismal development | |
| anatomical structure morphogenesis | |
| telencephalon development | |
| pallium development | |
| subpallium development | |
| forebrain morphogenesis | |
| inner ear morphogenesis | |
| limb morphogenesis | |
| embryonic hindlimb morphogenesis | |
| gastrulation | |
| neural plate morphogenesis | |
| salivary gland morphogenesis | |
| ureteric bud branching | |
| heart morphogenesis | |
| lung morphogenesis | |
| blood vessel remodeling | |
| heart looping | |
| forebrain dorsal-ventral pattern formation | |
| heart development | |
| lung development | |
| kidney development | |
| male genitalia development | |
| embryonic heart tube development | |
| embryonic development ending in birth or egg hatching | |
| determination of left-right symmetry | |
| response to oxidative stress |
| Rat chromosome position | 1q54 |
|---|
| Group | GF |
|---|---|
| extracellular region | |
| external side of plasma membrane | |
| chemoattractant activity | |
| growth factor activity | |
| patterning of blood vessels | |
| induction of an organ | |
| negative regulation of apoptosis | |
| negative regulation of neuron apoptosis | |
| positive regulation of cell proliferation | |
| positive regulation of mitosis | |
| positive regulation of gene expression | |
| signal transduction | |
| fibroblast growth factor receptor signaling pathway | |
| MAPKKK cascade | |
| cell proliferation | |
| apoptosis | |
| dorsal-ventral axon guidance | |
| motor axon guidance | |
| cell proliferation in forebrain | |
| cell fate commitment | |
| generation of neurons | |
| forebrain neuron development | |
| central nervous system neuron development | |
| multicellular organismal development | |
| anatomical structure morphogenesis | |
| telencephalon development | |
| pallium development | |
| subpallium development | |
| forebrain morphogenesis | |
| inner ear morphogenesis | |
| limb morphogenesis | |
| embryonic hindlimb morphogenesis | |
| gastrulation | |
| neural plate morphogenesis | |
| salivary gland morphogenesis | |
| ureteric bud branching | |
| heart morphogenesis | |
| lung morphogenesis | |
| blood vessel remodeling | |
| heart looping | |
| forebrain dorsal-ventral pattern formation | |
| heart development | |
| lung development | |
| kidney development | |
| male genitalia development | |
| embryonic heart tube development | |
| embryonic development ending in birth or egg hatching | |
| determination of left-right symmetry | |
| response to oxidative stress |
| RGD ID | 70891 |
|---|
| LocusLink ID | 2253 |
|---|---|
| 14179 | |
| 29349 |
| Alias | AIGF |
|---|---|
| KAL6 | |
| HBGF-8 | |
| MGC149376 | |
| fibroblast growth factor 8 | |
| OTTHUMP00000020348 | |
| OTTHUMP00000020349 | |
| OTTHUMP00000020350 | |
| OTTHUMP00000020351 | |
| androgen-induced growth factor | |
| Fgf-8 | |
| MGC59627 | |
| OTTMUSP00000024240 | |
| fibroblast growth factor 8 (androgen-induced) | |
| androgen-induced fibroblast growth factor | |
| Fibroblast growth factor-8 | |
| fibroblast growth factor 8 isoform A precursor | |
| fibroblast growth factor 8 isoform F precursor | |
| fibroblast growth factor 8 isoform B precursor | |
| Fgf8 | |
| fibroblast growth factor 8 isoform E precursor | |
| Fibroblast growth factor VIII | |
| FGF8_MOUSE |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 600483 |
|---|---|
| 612702 |