| URN | urn:agi-llid:3557 |
|---|---|
| Name | IL1RN |
| Description | interleukin 1 receptor antagonist |
| Connectivity | 152 |
| Notes | The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. |
| Swiss-Prot Accession | P18510 |
|---|---|
| Q53SC2 | |
| A8K4G1 | |
| Q9UP87 | |
| P25085 | |
| Q542C7 | |
| Q542W1 | |
| Q3TBV5 | |
| Q8CGA1 | |
| P25086 | |
| Q99PV4 |
| Unigene ID | Hs.81134 |
|---|---|
| Mm.882 | |
| Rn.162640 |
| KEGG ID | hsa:3557 |
|---|---|
| mmu:16181 | |
| rno:60582 |
| Swiss-Prot ID | IL1RA_HUMAN |
|---|---|
| IL1RA_MOUSE | |
| IL1RA_RAT | |
| A8K4G1_HUMAN | |
| Q53SC2_HUMAN | |
| Q3TBV5_MOUSE | |
| Q542C7_MOUSE | |
| Q542W1_MOUSE |
| Cell Localization | Extracellular |
|---|
| GO ID | 0005125 |
|---|---|
| 0005152 | |
| 0005515 | |
| 0006955 | |
| 0006954 | |
| 0051384 | |
| 0005737 | |
| 0005576 | |
| 0005615 | |
| 0005622 | |
| 0005149 | |
| 0004872 | |
| 0030073 | |
| 0006629 | |
| 0031982 | |
| 0005150 | |
| 0002439 | |
| 0007565 | |
| 0001660 | |
| 0007613 | |
| 0043066 | |
| 0014050 | |
| 0009968 | |
| 0043507 | |
| 0042493 | |
| 0032496 | |
| 0014070 | |
| 0010243 | |
| 0007166 | |
| 0005887 |
| Pathway | IL-1Ra Effects |
|---|---|
| PPARbeta BCL6 Targets | |
| VDR Targets |
| IPI ID | IPI00000045 |
|---|---|
| IPI00175024 | |
| IPI00218573 | |
| IPI00174541 | |
| IPI00136858 | |
| IPI00466271 | |
| IPI00751888 | |
| IPI00752375 | |
| IPI00214461 | |
| IPI00882400 |
| Ariadne Ontology | IL1i |
|---|
| Mouse chromosome position | 2 10.0 cM |
|---|
| GO Molecular Function | protein binding |
|---|---|
| cytokine activity | |
| interleukin-1 receptor antagonist activity | |
| interleukin-1 receptor binding | |
| interleukin-1, Type I receptor binding | |
| receptor activity |
| Homologene ID | 11163 |
|---|
| Hugo ID | 6000 |
|---|
| GO Cellular Component | extracellular region |
|---|---|
| intracellular | |
| cytoplasm | |
| extracellular space | |
| vesicle |
| MGI ID | 96547 |
|---|
| Human chromosome position | 2q14.2 |
|---|
| GO Biological Process | negative regulation of glutamate secretion |
|---|---|
| negative regulation of signal transduction | |
| negative regulation of apoptosis | |
| positive regulation of JUN kinase activity | |
| fever | |
| insulin secretion | |
| immune response | |
| chronic inflammatory response to antigenic stimulus | |
| lipid metabolic process | |
| female pregnancy | |
| response to lipopolysaccharide | |
| memory | |
| response to drug | |
| response to glucocorticoid stimulus | |
| response to organic nitrogen | |
| response to organic cyclic substance | |
| inflammatory response |
| Rat chromosome position | 3p13 |
|---|
| Group | IL1i |
|---|---|
| extracellular region | |
| intracellular | |
| cytoplasm | |
| extracellular space | |
| vesicle | |
| protein binding | |
| cytokine activity | |
| interleukin-1 receptor antagonist activity | |
| interleukin-1 receptor binding | |
| interleukin-1, Type I receptor binding | |
| receptor activity | |
| negative regulation of glutamate secretion | |
| negative regulation of signal transduction | |
| negative regulation of apoptosis | |
| positive regulation of JUN kinase activity | |
| fever | |
| insulin secretion | |
| immune response | |
| chronic inflammatory response to antigenic stimulus | |
| lipid metabolic process | |
| female pregnancy | |
| response to lipopolysaccharide | |
| memory | |
| response to drug | |
| response to glucocorticoid stimulus | |
| response to organic nitrogen | |
| response to organic cyclic substance | |
| inflammatory response |
| RGD ID | 621159 |
|---|
| LocusLink ID | 3557 |
|---|---|
| 16181 | |
| 60582 |
| Alias | IRAP |
|---|---|
| IL1F3 | |
| IL1RA | |
| IL-1ra3 | |
| ICIL-1RA | |
| MGC10430 | |
| interleukin 1 receptor antagonist | |
| IL1RN (IL1F3) | |
| type II interleukin-1 receptor antagonist | |
| intracellular IL-1 receptor antagonist type II | |
| intracellular interleukin-1 receptor antagonist (icIL-1ra) | |
| IL-1ra | |
| F630041P17Rik | |
| RP23-218B17.2 | |
| OTTMUSP00000012801 | |
| OTTMUSP00000012802 | |
| IL-1RNs | |
| ICIL- 1RA | |
| IL-1RN | |
| IL1X_HUMAN | |
| IL1X | |
| interleukin-1 receptor antagonist secreted form precursor | |
| intracellular interleukin-1 receptor antagonist | |
| RIKEN cDNA F630041P17 gene | |
| Il1rn |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 147679 |
|---|---|
| 137215 |