| URN | urn:agi-llid:185 |
|---|---|
| Name | AGTR1 |
| Description | angiotensin II receptor, type 1a |
| Connectivity | 948 |
| Notes | receptor for and mediator of vascular remodeling effects of angiotensin II [RGD] |
| Swiss-Prot Accession | P30556 |
|---|---|
| Q53YY0 | |
| Q6NUP5 | |
| Q8TBK4 | |
| P29754 | |
| P25095 | |
| Q5SVY5 | |
| Q13725 |
| Unigene ID | Hs.477887 |
|---|---|
| Hs.714694 | |
| Mm.35062 | |
| Mm.477038 | |
| Rn.9814 | |
| Rn.214849 | |
| Hs.709185 | |
| Mm.467335 |
| KEGG ID | hsa:185 |
|---|---|
| rno:24180 | |
| mmu:11607 |
| Swiss-Prot ID | AGTR1_HUMAN |
|---|---|
| AGTRA_MOUSE | |
| AGTRA_RAT | |
| Q53YY0_HUMAN |
| Cell Localization | Plasma membrane |
|---|
| GO ID | 0004930 |
|---|---|
| 0010698 | |
| 0001596 | |
| 0004945 | |
| 0031711 | |
| 0046982 | |
| 0004872 | |
| 0019722 | |
| 0051482 | |
| 0001822 | |
| 0034374 | |
| 0006800 | |
| 0033864 | |
| 0032270 | |
| 0010744 | |
| 0050729 | |
| 0032430 | |
| 0045940 | |
| 0002034 | |
| 0001558 | |
| 0042127 | |
| 0003078 | |
| 0019229 | |
| 0042312 | |
| 0002018 | |
| 0007165 | |
| 0005887 | |
| 0005886 | |
| 0005515 | |
| 0004871 | |
| 0007186 | |
| 0001568 | |
| 0002035 | |
| 0042756 | |
| 0043524 | |
| 0045777 | |
| 0002019 | |
| 0001991 | |
| 0002001 | |
| 0005737 | |
| 0005768 | |
| 0016021 | |
| 0016020 | |
| 0001965 | |
| 0017046 | |
| 0043621 | |
| 0007200 | |
| 0007204 | |
| 0001921 | |
| 0008217 | |
| 0006885 | |
| 0043627 | |
| 0005794 | |
| 0016323 | |
| 0031410 | |
| 0030425 | |
| 0012505 | |
| 0031968 | |
| 0031983 | |
| 0012506 | |
| 0016494 | |
| 0004947 | |
| 0001584 | |
| 0008015 | |
| 0007589 |
| Pathway | AngiotensinR -> CREB/ELK-SRF/TP53 signaling |
|---|---|
| AngiotensinR -> STAT signaling | |
| CVD and receptors (all) | |
| CVD and receptors (all) + Ligands | |
| PPARG Targets | |
| VDR Targets |
| IPI ID | IPI00026885 |
|---|---|
| IPI00797565 | |
| IPI00129168 | |
| IPI00327967 |
| Ariadne Ontology | GPCR-G12CR |
|---|
| Mouse chromosome position | 13 16.0 cM |
|---|
| GO Molecular Function | protein binding |
|---|---|
| peptide hormone binding | |
| angiotensin type I receptor activity | |
| angiotensin type II receptor activity | |
| protein self-association | |
| G-protein alpha-subunit binding | |
| protein heterodimerization activity | |
| bradykinin receptor binding | |
| acetyltransferase activator activity | |
| signal transducer activity | |
| receptor activity | |
| G-protein coupled receptor activity |
| Homologene ID | 3556 |
|---|
| Hugo ID | 336 |
|---|
| GO Cellular Component | endomembrane system |
|---|---|
| membrane | |
| dendrite | |
| vesicle membrane | |
| organelle outer membrane | |
| cytoplasm | |
| endosome | |
| cytoplasmic vesicle | |
| Golgi apparatus | |
| plasma membrane | |
| integral to membrane | |
| integral to plasma membrane | |
| basolateral plasma membrane | |
| vesicle lumen |
| MGI ID | 87964 |
|---|
| Human chromosome position | 3q21-q25 |
|---|
| GO Biological Process | negative regulation of neuron apoptosis |
|---|---|
| positive regulation of foam cell differentiation | |
| positive regulation of cellular protein metabolic process | |
| positive regulation of steroid metabolic process | |
| positive regulation of receptor recycling | |
| positive regulation of inflammatory response | |
| signal transduction | |
| regulation of cell growth | |
| regulation of cell proliferation | |
| G-protein coupled receptor protein signaling pathway | |
| activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger | |
| elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) | |
| calcium-mediated signaling | |
| regulation of natriuresis | |
| regulation of vasoconstriction | |
| regulation of vasodilation | |
| regulation of blood pressure | |
| positive regulation of blood pressure | |
| elevation of cytosolic calcium ion concentration | |
| regulation of pH | |
| brain renin-angiotensin system | |
| regulation of blood vessel size by renin-angiotensin | |
| regulation of systemic arterial blood pressure by circulatory renin-angiotensin | |
| regulation of renal output by angiotensin | |
| renin-angiotensin regulation of aldosterone production | |
| renin secretion into blood stream | |
| positive regulation of phospholipase A2 activity | |
| positive regulation of NAD(P)H oxidase activity | |
| low-density lipoprotein particle remodeling | |
| oxygen and reactive oxygen species metabolic process | |
| kidney development | |
| blood vessel development | |
| drinking behavior | |
| response to estrogen stimulus |
| Rat chromosome position | 17q12 |
|---|
| Group | GPCR-G12CR |
|---|---|
| endomembrane system | |
| membrane | |
| dendrite | |
| vesicle membrane | |
| organelle outer membrane | |
| cytoplasm | |
| endosome | |
| cytoplasmic vesicle | |
| Golgi apparatus | |
| plasma membrane | |
| integral to membrane | |
| integral to plasma membrane | |
| basolateral plasma membrane | |
| vesicle lumen | |
| protein binding | |
| peptide hormone binding | |
| angiotensin type I receptor activity | |
| angiotensin type II receptor activity | |
| protein self-association | |
| G-protein alpha-subunit binding | |
| protein heterodimerization activity | |
| bradykinin receptor binding | |
| acetyltransferase activator activity | |
| signal transducer activity | |
| receptor activity | |
| G-protein coupled receptor activity | |
| negative regulation of neuron apoptosis | |
| positive regulation of foam cell differentiation | |
| positive regulation of cellular protein metabolic process | |
| positive regulation of steroid metabolic process | |
| positive regulation of receptor recycling | |
| positive regulation of inflammatory response | |
| signal transduction | |
| regulation of cell growth | |
| regulation of cell proliferation | |
| G-protein coupled receptor protein signaling pathway | |
| activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger | |
| elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) | |
| calcium-mediated signaling | |
| regulation of natriuresis | |
| regulation of vasoconstriction | |
| regulation of vasodilation | |
| regulation of blood pressure | |
| positive regulation of blood pressure | |
| elevation of cytosolic calcium ion concentration | |
| regulation of pH | |
| brain renin-angiotensin system | |
| regulation of blood vessel size by renin-angiotensin | |
| regulation of systemic arterial blood pressure by circulatory renin-angiotensin | |
| regulation of renal output by angiotensin | |
| renin-angiotensin regulation of aldosterone production | |
| renin secretion into blood stream | |
| positive regulation of phospholipase A2 activity | |
| positive regulation of NAD(P)H oxidase activity | |
| low-density lipoprotein particle remodeling | |
| oxygen and reactive oxygen species metabolic process | |
| kidney development | |
| blood vessel development | |
| drinking behavior | |
| response to estrogen stimulus |
| RGD ID | 2070 |
|---|
| LocusLink ID | 185 |
|---|---|
| 11607 | |
| 24180 |
| Alias | AT1 |
|---|---|
| AG2S | |
| AT1B | |
| AT1R | |
| AT2R1 | |
| HAT1R | |
| AGTR1A | |
| AGTR1B | |
| AT2R1A | |
| AT2R1B | |
| angiotensin II receptor, type 1 | |
| angiotensin receptor 1 | |
| angiotensin receptor 1B | |
| type-1B angiotensin II receptor | |
| AT1a | |
| Agtr1 | |
| Agtr-1a | |
| AI551199 | |
| Angtr-1a | |
| MGC37610 | |
| 1810074K20Rik | |
| angiotensin II receptor, type 1a | |
| OTTMUSP00000000614 | |
| angiotensin receptor 1a | |
| vascular type-1 angiotensin II receptor | |
| AT1AR | |
| Type-1 angiotensin II receptor | |
| angiotensin II receptor, type I | |
| AT1 receptor | |
| angiotensin II type-1 receptor | |
| angiotensin receptor I | |
| AT1A receptor | |
| AGTR I | |
| AT2R I | |
| Angtr-1b | |
| RIKEN cDNA 1810074K20 gene | |
| AT1A receptors | |
| AT1 receptors | |
| angiotensin II type-1 receptors | |
| type-1B angiotensin II receptors | |
| Type-1 angiotensin II receptors | |
| angiotensin ii receptor, type 1b | |
| angiotensin II receptor, type 1 (AT1A) | |
| Angiotensin II receptor, type 1 (AT1B) | |
| AT>1A< receptor | |
| AT>1A< receptors | |
| expressed sequence AI551199 | |
| AT-1 | |
| AT(1) | |
| AT(3) |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 106165 |
|---|---|
| 145500 | |
| 267430 |