| URN | urn:agi-llid:22943 |
|---|---|
| Name | DKK1 |
| Description | dickkopf homolog 1 (Xenopus laevis) |
| Connectivity | 216 |
| Notes | This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma. [provided by RefSeq] |
| Swiss-Prot Accession | B2RC19 |
|---|---|
| O94907 | |
| Q80UL5 | |
| O54908 |
| Unigene ID | Hs.40499 |
|---|---|
| Mm.214717 | |
| Rn.214343 |
| KEGG ID | hsa:22943 |
|---|---|
| mmu:13380 | |
| rno:293897 |
| Swiss-Prot ID | DKK1_HUMAN |
|---|---|
| B2RC19_HUMAN | |
| Q80UL5_MOUSE |
| Cell Localization | Extracellular |
|---|
| GO ID | 0008083 |
|---|---|
| 0050750 | |
| 0005515 | |
| 0004871 | |
| 0030326 | |
| 0030900 | |
| 0007275 | |
| 0030178 | |
| 0005576 | |
| 0005886 | |
| 0016055 | |
| 0030111 |
| Pathway | VDR Targets |
|---|
| IPI ID | IPI00016353 |
|---|---|
| IPI00330317 | |
| IPI00387211 | |
| IPI00361250 |
| Ariadne Ontology | DKK |
|---|
| Mouse chromosome position | 19 C2 |
|---|
| GO Molecular Function | protein binding |
|---|---|
| growth factor activity | |
| low-density lipoprotein receptor binding | |
| signal transducer activity |
| Homologene ID | 7689 |
|---|
| Hugo ID | 2891 |
|---|
| GO Cellular Component | extracellular region |
|---|---|
| plasma membrane |
| MGI ID | 1329040 |
|---|
| Human chromosome position | 10q11.2 |
|---|
| GO Biological Process | negative regulation of Wnt receptor signaling pathway |
|---|---|
| regulation of Wnt receptor signaling pathway | |
| Wnt receptor signaling pathway | |
| multicellular organismal development | |
| forebrain development | |
| embryonic limb morphogenesis |
| Rat chromosome position | 1q52 |
|---|
| Group | DKK |
|---|---|
| extracellular region | |
| plasma membrane | |
| protein binding | |
| growth factor activity | |
| low-density lipoprotein receptor binding | |
| signal transducer activity | |
| negative regulation of Wnt receptor signaling pathway | |
| regulation of Wnt receptor signaling pathway | |
| Wnt receptor signaling pathway | |
| multicellular organismal development | |
| forebrain development | |
| embryonic limb morphogenesis |
| RGD ID | 1307313 |
|---|
| LocusLink ID | 22943 |
|---|---|
| 13380 | |
| 293897 |
| Alias | SK |
|---|---|
| DKK-1 | |
| dickkopf homolog 1 | |
| dickkopf-1 like | |
| OTTHUMP00000019617 | |
| dickkopf related protein-1 | |
| mdkk-1 | |
| OTTMUSP00000022079 | |
| dickkopf homolog 1 (Xenopus laevis) | |
| hDkk I | |
| mdkk I | |
| Dkk I | |
| dickkopf (Xenopus laevis) homolog I | |
| dickkopf homolog I | |
| dickkopf (Xenopus laevis) homolog 1 | |
| Dickkopf related protein-1 precursor | |
| dickkopf-1 | |
| Dkk1 | |
| hDkk-1 | |
| dickkopf I |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 605189 |
|---|