Protein PPARD

URN	urn:agi-llid:5467
Name	PPARD
Description	peroxisome proliferator-activated receptor delta
Connectivity	483
Notes	This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation.

Cell Localization	Nucleus

Pathway	NIH Omega 3
	BCL6
	HepG2 Extracts
	MR 05/06/09 14:12:19
	MR 05/06/09 14:18:08
	Cardiovascular Disease (Large)
	CVD Transcription factors
	'CVD Transcription factors' + Ligands
	CVD and receptors
	CVD and receptors (all)
	CVD and receptors (all) + Ligands
	Figure 3 CAR 2009
	PPARbeta BCL6 Targets
	PPARG Targets
	PPARbeta Targets
	VDR Targets

Ariadne Ontology	Thr-like

Mouse chromosome position	17 13.5 cM

GO Molecular Function	protein binding
	drug binding
	metal ion binding
	zinc ion binding
	fatty acid binding
	DNA binding
	sequence-specific DNA binding
	transcription factor activity
	protein heterodimerization activity
	retinoid X receptor binding
	NF-kappaB binding
	enzyme activator activity
	receptor activity
	ligand-dependent nuclear receptor activity
	steroid hormone receptor activity
	prostacyclin receptor activity
	transcription repressor activity

Homologene ID	4544

Hugo ID	9235

GO Cellular Component	nucleus

MGI ID	101884

Human chromosome position	6p21.2-p21.1

GO Biological Process	cellular process
	cell-substrate adhesion
	negative regulation of I-kappaB kinase-NF-kappaB cascade
	negative regulation of epithelial cell proliferation
	negative regulation of transcription from RNA polymerase II promoter
	positive regulation of cell proliferation
	positive regulation of phosphoinositide 3-kinase cascade
	positive regulation of fat cell differentiation
	regulation of cell proliferation
	regulation of insulin secretion
	regulation of fat cell differentiation
	regulation of transcription, DNA-dependent
	axon ensheathment
	cell proliferation
	apoptosis
	keratinocyte migration
	keratinocyte proliferation
	cell differentiation
	generation of precursor metabolites and energy
	glucose metabolic process
	cholesterol metabolic process
	transcription
	fatty acid beta-oxidation
	fatty acid oxidation
	vitamin A metabolic process
	embryo implantation
	placenta development
	decidualization
	epidermis development
	anagen
	glucose transport
	fatty acid transport
	lipid metabolic process
	response to pain
	response to temperature stimulus
	wound healing

Rat chromosome position	20p12

Group	Thr-like
	nucleus
	protein binding
	drug binding
	metal ion binding
	zinc ion binding
	fatty acid binding
	DNA binding
	sequence-specific DNA binding
	transcription factor activity
	protein heterodimerization activity
	retinoid X receptor binding
	NF-kappaB binding
	enzyme activator activity
	receptor activity
	ligand-dependent nuclear receptor activity
	steroid hormone receptor activity
	prostacyclin receptor activity
	transcription repressor activity
	cellular process
	cell-substrate adhesion
	negative regulation of I-kappaB kinase-NF-kappaB cascade
	negative regulation of epithelial cell proliferation
	negative regulation of transcription from RNA polymerase II promoter
	positive regulation of cell proliferation
	positive regulation of phosphoinositide 3-kinase cascade
	positive regulation of fat cell differentiation
	regulation of cell proliferation
	regulation of insulin secretion
	regulation of fat cell differentiation
	regulation of transcription, DNA-dependent
	axon ensheathment
	cell proliferation
	apoptosis
	keratinocyte migration
	keratinocyte proliferation
	cell differentiation
	generation of precursor metabolites and energy
	glucose metabolic process
	cholesterol metabolic process
	transcription
	fatty acid beta-oxidation
	fatty acid oxidation
	vitamin A metabolic process
	embryo implantation
	placenta development
	decidualization
	epidermis development
	anagen
	glucose transport
	fatty acid transport
	lipid metabolic process
	response to pain
	response to temperature stimulus
	wound healing

MedScan ID	5467

RGD ID	3370

Alias	FAAR
	NUC1
	NUCI
	NR1C2
	NUCII
	PPARB
	MGC3931
	PPAR-beta
	peroxisome proliferative activated receptor, delta
	OTTHUMP00000016256
	nuclear hormone receptor 1
	NUC-1
	PPAR[b]
	Pparb/d
	PPARdelta
	PPAR-delta
	peroxisome proliferator activator receptor delta
	mPPAR(delta)
	PPARdelta/beta
	OTTMUSP00000027308
	Peroxisome proliferator-activated receptor beta
	peroxisome proliferator-activated receptor delta
	peroxisome proliferator activator receptor beta
	peroxisome proliferator activated receptor delta
	peroxisome proliferator activator receptor, delta
	PPAR(b)
	Ppard
	Peroxisome proliferator activated receptor beta
	PPAR- delta
	Nuclear hormone receptor I
	NUC I
	Pparb/ds
	PPAR[b]s
	mppar
	peroxisome proliferator activator receptor

OMIM ID	600409