| URN | urn:agi-llid:760 |
|---|---|
| Name | CA2 |
| Description | carbonic anhydrase II |
| Connectivity | 124 |
| Notes | CA2 is one of several (at least 7) isozymes of carbonic anhydrase. Carbonic anhydrase catalyzes reversible hydration of carbon dioxide. Defects in this enzyme are associated with osteopetrosis and renal tubular acidosis. [provided by RefSeq] |
| Swiss-Prot Accession | B2R7G8 |
|---|---|
| P00918 | |
| Q6LD99 | |
| P00920 | |
| P27139 |
| Unigene ID | Hs.155097 |
|---|---|
| Mm.1186 | |
| Rn.26083 |
| KEGG ID | hsa:760 |
|---|---|
| mmu:12349 | |
| rno:54231 |
| EC Number | 4.2.1.1 |
|---|
| Swiss-Prot ID | CAH2_HUMAN |
|---|---|
| CAH2_MOUSE | |
| CAH2_RAT | |
| B2R7G8_HUMAN |
| GO ID | 0004089 |
|---|---|
| 0016829 | |
| 0046872 | |
| 0008270 | |
| 0015670 | |
| 0002009 | |
| 0006730 | |
| 0046903 | |
| 0005737 | |
| 0005634 | |
| 0005515 | |
| 0001822 | |
| 0042475 | |
| 0030316 | |
| 0045780 | |
| 0032849 | |
| 0045672 | |
| 0045124 | |
| 0030641 | |
| 0043627 | |
| 0010033 | |
| 0009268 | |
| 0048545 | |
| 0006950 | |
| 0010043 | |
| 0045177 | |
| 0030424 | |
| 0016323 | |
| 0005615 | |
| 0005902 |
| Pathway | VDR Targets |
|---|
| IPI ID | IPI00218414 |
|---|---|
| IPI00790885 | |
| IPI00121534 | |
| IPI00230787 |
| Mouse chromosome position | 3 10.5 cM |
|---|
| GO Molecular Function | protein binding |
|---|---|
| metal ion binding | |
| zinc ion binding | |
| lyase activity | |
| carbonate dehydratase activity |
| Homologene ID | 37256 |
|---|
| Hugo ID | 1373 |
|---|
| GO Cellular Component | apical part of cell |
|---|---|
| microvillus | |
| axon | |
| cytoplasm | |
| nucleus | |
| basolateral plasma membrane | |
| extracellular space |
| MGI ID | 88269 |
|---|
| Human chromosome position | 8q22 |
|---|
| GO Biological Process | positive regulation of cellular pH reduction |
|---|---|
| positive regulation of osteoclast differentiation | |
| positive regulation of bone resorption | |
| regulation of bone resorption | |
| regulation of cellular pH | |
| osteoclast differentiation | |
| one-carbon compound metabolic process | |
| odontogenesis of dentine-containing tooth | |
| morphogenesis of an epithelium | |
| kidney development | |
| secretion | |
| carbon dioxide transport | |
| response to stress | |
| response to pH | |
| response to organic substance | |
| response to steroid hormone stimulus | |
| response to estrogen stimulus | |
| response to zinc ion |
| Rat chromosome position | 2q23 |
|---|
| Group | apical part of cell |
|---|---|
| microvillus | |
| axon | |
| cytoplasm | |
| nucleus | |
| basolateral plasma membrane | |
| extracellular space | |
| protein binding | |
| metal ion binding | |
| zinc ion binding | |
| lyase activity | |
| carbonate dehydratase activity | |
| positive regulation of cellular pH reduction | |
| positive regulation of osteoclast differentiation | |
| positive regulation of bone resorption | |
| regulation of bone resorption | |
| regulation of cellular pH | |
| osteoclast differentiation | |
| one-carbon compound metabolic process | |
| odontogenesis of dentine-containing tooth | |
| morphogenesis of an epithelium | |
| kidney development | |
| secretion | |
| carbon dioxide transport | |
| response to stress | |
| response to pH | |
| response to organic substance | |
| response to steroid hormone stimulus | |
| response to estrogen stimulus | |
| response to zinc ion |
| RGD ID | 2240 |
|---|
| LocusLink ID | 760 |
|---|---|
| 12349 | |
| 54231 |
| Alias | CAII |
|---|---|
| Car2 | |
| CA-II | |
| carbonic anhydrase II | |
| carbonic anhydrase B | |
| carbonic dehydratase | |
| carbonate dehydratase II | |
| Car-2 | |
| Ltw-5 | |
| Lvtw-5 | |
| AI131712 | |
| CA II | |
| Ca2 | |
| carbonic anhydrase 2 | |
| Ltw V | |
| Lvtw V | |
| CA 2 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 611492 |
|---|---|
| 259730 |