| URN | urn:agi-llid:3269 |
|---|---|
| Name | HRH1 |
| Description | histamine receptor H1 |
| Connectivity | 297 |
| Notes | Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. This gene was thought to be intronless until recently. The protein encoded by this gene is an integral membrane protein and belongs to the G protein-coupled receptor superfamily. It mediates the contraction of smooth muscles, the increase in capillary permeability due to contraction of terminal venules, the release of catecholamine from adrenal medulla, and neurotransmission in the central nervous system. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq] |
| Swiss-Prot Accession | A8K047 |
|---|---|
| P35367 | |
| Q6P9E5 | |
| B3Y5T0 | |
| P70174 | |
| P31390 | |
| Q91V49 | |
| Q91V66 |
| Unigene ID | Hs.1570 |
|---|---|
| Mm.333327 | |
| Rn.81032 | |
| Rn.177519 |
| KEGG ID | hsa:3269 |
|---|---|
| mmu:15465 | |
| rno:24448 |
| Swiss-Prot ID | HRH1_HUMAN |
|---|---|
| HRH1_MOUSE | |
| HRH1_RAT | |
| A8K047_HUMAN | |
| Q6P9E5_HUMAN | |
| B3Y5T0_MOUSE |
| Cell Localization | Plasma membrane |
|---|
| GO ID | 0004930 |
|---|---|
| 0004969 | |
| 0004872 | |
| 0007200 | |
| 0006954 | |
| 0045429 | |
| 0007165 | |
| 0007268 | |
| 0005887 | |
| 0005886 | |
| 0004871 | |
| 0007186 | |
| 0048511 | |
| 0016021 | |
| 0016020 | |
| 0007199 |
| Pathway | VDR Targets |
|---|
| IPI ID | IPI00018147 |
|---|---|
| IPI00136348 | |
| IPI00211814 | |
| IPI00454361 |
| Ariadne Ontology | GPCR-GqCR |
|---|
| Mouse chromosome position | 6 49.0 cM |
|---|
| GO Molecular Function | signal transducer activity |
|---|---|
| receptor activity | |
| G-protein coupled receptor activity | |
| histamine receptor activity |
| Homologene ID | 668 |
|---|
| Hugo ID | 5182 |
|---|
| GO Cellular Component | membrane |
|---|---|
| plasma membrane | |
| integral to membrane | |
| integral to plasma membrane |
| MGI ID | 107619 |
|---|
| Human chromosome position | 3p25 |
|---|
| GO Biological Process | rhythmic process |
|---|---|
| positive regulation of nitric oxide biosynthetic process | |
| signal transduction | |
| G-protein coupled receptor protein signaling pathway | |
| activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger | |
| G-protein signaling, coupled to cGMP nucleotide second messenger | |
| synaptic transmission | |
| inflammatory response |
| Rat chromosome position | 4q42 |
|---|
| Group | GPCR-GqCR |
|---|---|
| membrane | |
| plasma membrane | |
| integral to membrane | |
| integral to plasma membrane | |
| signal transducer activity | |
| receptor activity | |
| G-protein coupled receptor activity | |
| histamine receptor activity | |
| rhythmic process | |
| positive regulation of nitric oxide biosynthetic process | |
| signal transduction | |
| G-protein coupled receptor protein signaling pathway | |
| activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger | |
| G-protein signaling, coupled to cGMP nucleotide second messenger | |
| synaptic transmission | |
| inflammatory response |
| RGD ID | 2830 |
|---|
| LocusLink ID | 3269 |
|---|---|
| 15465 | |
| 24448 |
| Alias | H1-R |
|---|---|
| hisH1 | |
| histamine receptor H1 | |
| OTTHUMP00000160133 | |
| histamine H(1) receptor | |
| histamine receptor, subclass H1 | |
| Bphs | |
| Histamine H1 receptor | |
| Bordetella pertussis induced histamine sensitization | |
| Hisr | |
| histamine receptor H 1 | |
| histamine receptor H I | |
| histamine receptor, subclass H | |
| hisH I | |
| Histamine H1 receptors | |
| H1 Histamine receptor | |
| H1 Histamine receptors | |
| H1 receptor | |
| H1 receptors | |
| H(1)Rs | |
| H1Rs | |
| H1-Rs | |
| H1r | |
| H(1)R |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 600167 |
|---|