| URN | urn:agi-llid:85480 |
|---|---|
| Name | TSLP |
| Description | thymic stromal lymphopoietin |
| Connectivity | 138 |
| Notes | This gene encodes a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. It mainly impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c(+) dendritic cells. Alternative splicing of this gene results in two transcript variants. [provided by RefSeq] |
| Swiss-Prot Accession | Q969D9 |
|---|---|
| Q96AU7 | |
| Q9JIE6 |
| Unigene ID | Hs.389874 |
|---|---|
| Mm.143716 | |
| Rn.201724 |
| KEGG ID | hsa:85480 |
|---|---|
| mmu:53603 |
| Swiss-Prot ID | TSLP_HUMAN |
|---|---|
| TSLP_MOUSE |
| Cell Localization | Extracellular |
|---|
| GO ID | 0005125 |
|---|---|
| 0005576 | |
| 0005615 |
| Pathway | VDR Targets |
|---|
| IPI ID | IPI00413782 |
|---|---|
| IPI00217207 | |
| IPI00120471 | |
| IPI00765119 |
| Ariadne Ontology | Cytokine |
|---|
| Mouse chromosome position | 18 11.0 cM |
|---|
| GO Molecular Function | cytokine activity |
|---|
| Homologene ID | 81957 |
|---|
| Hugo ID | 30743 |
|---|
| GO Cellular Component | extracellular region |
|---|---|
| extracellular space |
| MGI ID | 1855696 |
|---|
| Human chromosome position | 5q22.1 |
|---|
| Rat chromosome position | 18p12 |
|---|
| Group | Cytokine |
|---|---|
| extracellular region | |
| extracellular space | |
| cytokine activity |
| RGD ID | 1586479 |
|---|
| LocusLink ID | 85480 |
|---|---|
| 53603 | |
| 688621 |
| Alias | thymic stromal lymphopoietin |
|---|---|
| TSLP |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 607003 |
|---|