| URN | urn:agi-llid:5741 |
|---|---|
| Name | PTH |
| Description | parathyroid hormone |
| Connectivity | 857 |
| Notes | The protein encoded by this gene is a hormone secreted by parathyroid cells. This hormone elevates blood Ca2+ level by dissolving the salts in bone and preventing their renal excretion. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH). [provided by RefSeq] |
| Swiss-Prot Accession | P01270 |
|---|---|
| Q9UD38 | |
| Q9Z0L6 | |
| P04089 | |
| Q80WZ2 |
| Unigene ID | Hs.37045 |
|---|---|
| Mm.284168 | |
| Rn.9768 |
| KEGG ID | hsa:5741 |
|---|---|
| mmu:19226 | |
| rno:24694 |
| Swiss-Prot ID | PTHY_HUMAN |
|---|---|
| PTHY_RAT | |
| Q9Z0L6_MOUSE |
| Cell Localization | Extracellular |
|---|
| GO ID | 0005179 |
|---|---|
| 0031856 | |
| 0007186 | |
| 0007266 | |
| 0007189 | |
| 0045453 | |
| 0046058 | |
| 0007267 | |
| 0006874 | |
| 0008628 | |
| 0030819 | |
| 0009967 | |
| 0045944 | |
| 0010468 | |
| 0001501 | |
| 0005576 | |
| 0005615 | |
| 0001503 | |
| 0005575 |
| Pathway | VDR Targets |
|---|
| IPI ID | IPI00000940 |
|---|---|
| IPI00129238 | |
| IPI00192443 |
| Ariadne Ontology | Neuromodulator |
|---|
| Mouse chromosome position | 7 52.5 cM |
|---|
| GO Molecular Function | hormone activity |
|---|---|
| parathyroid hormone receptor binding |
| Homologene ID | 266 |
|---|
| Hugo ID | 9606 |
|---|
| GO Cellular Component | cellular_component |
|---|---|
| extracellular region | |
| extracellular space |
| MGI ID | 97799 |
|---|
| Human chromosome position | 11p15.3-p15.1 |
|---|
| GO Biological Process | positive regulation of signal transduction |
|---|---|
| induction of apoptosis by hormones | |
| positive regulation of cAMP biosynthetic process | |
| positive regulation of transcription from RNA polymerase II promoter | |
| activation of adenylate cyclase activity by G-protein signaling pathway | |
| G-protein coupled receptor protein signaling pathway | |
| Rho protein signal transduction | |
| regulation of gene expression | |
| bone resorption | |
| cellular calcium ion homeostasis | |
| cell-cell signaling | |
| cAMP metabolic process | |
| ossification | |
| skeletal system development |
| Rat chromosome position | 1q34 |
|---|
| Group | Neuromodulator |
|---|---|
| cellular_component | |
| extracellular region | |
| extracellular space | |
| hormone activity | |
| parathyroid hormone receptor binding | |
| positive regulation of signal transduction | |
| induction of apoptosis by hormones | |
| positive regulation of cAMP biosynthetic process | |
| positive regulation of transcription from RNA polymerase II promoter | |
| activation of adenylate cyclase activity by G-protein signaling pathway | |
| G-protein coupled receptor protein signaling pathway | |
| Rho protein signal transduction | |
| regulation of gene expression | |
| bone resorption | |
| cellular calcium ion homeostasis | |
| cell-cell signaling | |
| cAMP metabolic process | |
| ossification | |
| skeletal system development |
| RGD ID | 3440 |
|---|
| LocusLink ID | 5741 |
|---|---|
| 19226 | |
| 24694 |
| Alias | PTH1 |
|---|---|
| parathyroid hormone | |
| parathyrin | |
| parathormone | |
| parathyroid hormone 1 | |
| Pthp | |
| MGC117651 | |
| Pthr1 | |
| PTH-(1-84) | |
| hypothalamic parathyroid hormone | |
| Parathyroid hormone human | |
| Pth I | |
| Pth |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 168450 |
|---|---|
| 146200 |