| URN | urn:agi-llid:1634 |
|---|---|
| Name | DCN |
| Description | decorin |
| Connectivity | 310 |
| Notes | The protein encoded by this gene is a small cellular or pericellular matrix proteoglycan that is closely related in structure to biglycan protein. The encoded protein and biglycan are thought to be the result of a gene duplication. This protein is a component of connective tissue, binds to type I collagen fibrils, and plays a role in matrix assembly. It contains one attached glycosaminoglycan chain. This protein is capable of suppressing the growth of various tumor cell lines. There are multiple alternatively spliced transcript variants known for this gene. This gene is a candidate gene for Marfan syndrome. |
| Swiss-Prot Accession | P07585 |
|---|---|
| Q6FH10 | |
| P28654 | |
| Q3UKR1 | |
| Q3TSV1 | |
| Q6LAK9 | |
| Q01129 |
| Unigene ID | Hs.718429 |
|---|---|
| Mm.56769 | |
| Rn.106103 | |
| Hs.706840 |
| KEGG ID | hsa:1634 |
|---|---|
| mmu:13179 | |
| rno:29139 |
| Swiss-Prot ID | PGS2_HUMAN |
|---|---|
| PGS2_MOUSE | |
| PGS2_RAT | |
| Q6FH10_HUMAN | |
| Q3UKR1_MOUSE |
| Cell Localization | Extracellular |
|---|
| GO ID | 0005515 |
|---|---|
| 0009887 | |
| 0005576 | |
| 0005634 | |
| 0005578 | |
| 0050840 | |
| 0005539 | |
| 0019800 | |
| 0031012 | |
| 0005518 | |
| 0047485 | |
| 0030198 | |
| 0005615 |
| Pathway | PPARG Targets |
|---|---|
| FXR Targets | |
| PPARbeta Targets | |
| VDR Targets |
| IPI ID | IPI00012119 |
|---|---|
| IPI00219400 | |
| IPI00219401 | |
| IPI00219403 | |
| IPI00219404 | |
| IPI00873377 | |
| IPI00789871 | |
| IPI00792461 | |
| IPI00793118 | |
| IPI00123196 | |
| IPI00199861 |
| Ariadne Ontology | Extracellular matrix polymerization |
|---|
| Mouse chromosome position | 10 55.0 cM |
|---|
| GO Molecular Function | protein binding |
|---|---|
| extracellular matrix binding | |
| glycosaminoglycan binding | |
| protein N-terminus binding | |
| collagen binding |
| Homologene ID | 22430 |
|---|
| Hugo ID | 2705 |
|---|
| GO Cellular Component | extracellular region |
|---|---|
| nucleus | |
| extracellular matrix | |
| proteinaceous extracellular matrix |
| MGI ID | 94872 |
|---|
| Human chromosome position | 12q21.33 |
|---|
| GO Biological Process | extracellular matrix organization |
|---|---|
| peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan | |
| organ morphogenesis |
| Rat chromosome position | 7q13 |
|---|
| Group | Extracellular matrix polymerization |
|---|---|
| extracellular region | |
| nucleus | |
| extracellular matrix | |
| proteinaceous extracellular matrix | |
| protein binding | |
| extracellular matrix binding | |
| glycosaminoglycan binding | |
| protein N-terminus binding | |
| collagen binding | |
| extracellular matrix organization | |
| peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan | |
| organ morphogenesis |
| RGD ID | 61895 |
|---|
| LocusLink ID | 1634 |
|---|---|
| 13179 | |
| 29139 |
| Alias | CSCD |
|---|---|
| PG40 | |
| PGII | |
| PGS2 | |
| DSPG2 | |
| SLRR1B | |
| decorin | |
| bone proteoglycan II | |
| decorin proteoglycan | |
| proteoglycan core protein | |
| small leucine-rich protein 1B | |
| dermatan sulphate proteoglycans II | |
| DC | |
| mDcn | |
| MGC94682 | |
| dermatan sulfate proteoglycan-II (decorin) | |
| decorins | |
| Bone proteoglycan II precursor | |
| PG-S2 | |
| Dcn | |
| dermatan sulfate proteoglycan-ii |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 125255 |
|---|---|
| 610048 |