| URN | urn:agi-llid:4879 |
|---|---|
| Name | NPPB |
| Description | natriuretic peptide precursor B |
| Connectivity | 402 |
| Notes | This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. Mutations in this gene have been associated with postmenopausal osteoporosis. |
| Swiss-Prot Accession | P16860 |
|---|---|
| Q9P2Q7 |
| Unigene ID | Hs.219140 |
|---|
| KEGG ID | hsa:4879 |
|---|
| Swiss-Prot ID | ANFB_HUMAN |
|---|
| Cell Localization | Extracellular |
|---|
| GO ID | 0008613 |
|---|---|
| 0007166 | |
| 0030146 | |
| 0030147 | |
| 0016525 | |
| 0030308 | |
| 0008217 | |
| 0050880 | |
| 0043114 | |
| 0042312 | |
| 0005576 | |
| 0005615 | |
| 0005179 |
| Pathway | PPARG Targets |
|---|---|
| VDR Targets |
| IPI ID | IPI00031101 |
|---|---|
| IPI00844052 |
| Ariadne Ontology | GUC activator |
|---|
| GO Molecular Function | diuretic hormone activity |
|---|
| Hugo ID | 7940 |
|---|
| GO Cellular Component | extracellular region |
|---|---|
| extracellular space |
| Human chromosome position | 1p36.2 |
|---|
| GO Biological Process | negative regulation of angiogenesis |
|---|---|
| negative regulation of cell growth | |
| cell surface receptor linked signal transduction | |
| regulation of vasodilation | |
| regulation of blood pressure | |
| regulation of vascular permeability | |
| natriuresis | |
| diuresis | |
| regulation of blood vessel size |
| Group | GUC activator |
|---|---|
| extracellular region | |
| extracellular space | |
| diuretic hormone activity | |
| negative regulation of angiogenesis | |
| negative regulation of cell growth | |
| cell surface receptor linked signal transduction | |
| regulation of vasodilation | |
| regulation of blood pressure | |
| regulation of vascular permeability | |
| natriuresis | |
| diuresis | |
| regulation of blood vessel size |
| LocusLink ID | 4879 |
|---|
| Alias | BNP |
|---|---|
| natriuretic peptide precursor B | |
| OTTHUMP00000002506 | |
| OTTHUMP00000044486 | |
| natriuretic protein | |
| brain type natriuretic peptide | |
| NT-proBNP | |
| N-terminal pro-BNP | |
| B-type natriuretic peptide | |
| Brain natriuretic peptide precursor | |
| NPPB | |
| brain natriuretic factor |
| Organism | Homo sapiens |
|---|
| OMIM ID | 600295 |
|---|