| URN | urn:agi-llid:7015 |
|---|---|
| Name | TERT |
| Description | telomerase reverse transcriptase |
| Connectivity | 438 |
| Notes | Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity. [provided by RefSeq] |
| Swiss-Prot Accession | O14746 |
|---|---|
| O94807 | |
| Q8NG38 | |
| Q9UBR6 | |
| Q9UNR4 | |
| Q9UNS6 | |
| Q9UQ24 | |
| O70372 | |
| Q3UZL9 | |
| Q9JLM1 | |
| Q9R0B3 | |
| Q9R266 | |
| Q673L6 |
| Unigene ID | Hs.492203 |
|---|---|
| Mm.10109 | |
| Rn.48802 |
| KEGG ID | mmu:21752 |
|---|
| EC Number | 2.7.7.49 |
|---|
| Swiss-Prot ID | TERT_HUMAN |
|---|---|
| TERT_MOUSE | |
| TERT_RAT |
| Cell Localization | Nucleus |
|---|
| GO ID | 0003677 |
|---|---|
| 0016779 | |
| 0005515 | |
| 0042803 | |
| 0042162 | |
| 0070034 | |
| 0003721 | |
| 0016740 | |
| 0022616 | |
| 0006916 | |
| 0010149 | |
| 0032203 | |
| 0000723 | |
| 0007004 | |
| 0005694 | |
| 0000781 | |
| 0000783 | |
| 0005654 | |
| 0005634 | |
| 0005697 | |
| 0003723 | |
| 0003964 | |
| 0003720 | |
| 0006278 | |
| 0030529 | |
| 0008150 | |
| 0005737 |
| Pathway | VDR Targets |
|---|
| IPI ID | IPI00298218 |
|---|---|
| IPI00384469 | |
| IPI00168908 | |
| IPI00117405 | |
| IPI00371142 | |
| IPI00767323 | |
| IPI00388019 | |
| IPI00777834 |
| Ariadne Ontology | Telomere maintenance |
|---|
| Mouse chromosome position | 13 43.0 cM |
|---|
| GO Molecular Function | protein binding |
|---|---|
| RNA binding | |
| DNA binding | |
| telomeric DNA binding | |
| telomeric RNA binding | |
| protein homodimerization activity | |
| transferase activity | |
| nucleotidyltransferase activity | |
| RNA-directed DNA polymerase activity | |
| telomerase activity | |
| telomeric template RNA reverse transcriptase activity |
| Homologene ID | 31141 |
|---|
| Hugo ID | 11730 |
|---|
| GO Cellular Component | ribonucleoprotein complex |
|---|---|
| cytoplasm | |
| nucleus | |
| nucleoplasm | |
| telomerase holoenzyme complex | |
| nuclear telomere cap complex | |
| chromosome | |
| chromosome, telomeric region |
| MGI ID | 1202709 |
|---|
| Human chromosome position | 5p15.33 |
|---|
| GO Biological Process | biological_process |
|---|---|
| telomere formation via telomerase | |
| anti-apoptosis | |
| telomere maintenance | |
| telomere maintenance via telomerase | |
| RNA-dependent DNA replication | |
| DNA strand elongation | |
| senescence |
| Rat chromosome position | 1p11 |
|---|
| Group | Telomere maintenance |
|---|---|
| ribonucleoprotein complex | |
| cytoplasm | |
| nucleus | |
| nucleoplasm | |
| telomerase holoenzyme complex | |
| nuclear telomere cap complex | |
| chromosome | |
| chromosome, telomeric region | |
| protein binding | |
| RNA binding | |
| DNA binding | |
| telomeric DNA binding | |
| telomeric RNA binding | |
| protein homodimerization activity | |
| transferase activity | |
| nucleotidyltransferase activity | |
| RNA-directed DNA polymerase activity | |
| telomerase activity | |
| telomeric template RNA reverse transcriptase activity | |
| biological_process | |
| telomere formation via telomerase | |
| anti-apoptosis | |
| telomere maintenance | |
| telomere maintenance via telomerase | |
| RNA-dependent DNA replication | |
| DNA strand elongation | |
| senescence |
| RGD ID | 70494 |
|---|
| LocusLink ID | 7015 |
|---|---|
| 21752 | |
| 301965 |
| Alias | TP2 |
|---|---|
| TRT | |
| EST2 | |
| TCS1 | |
| hEST2 | |
| telomerase reverse transcriptase | |
| telomerase catalytic subunit | |
| TR | |
| MGC150124 | |
| hTERT | |
| Telomerase catalytic subunit | |
| TCS I | |
| TERT |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 187270 |
|---|---|
| 609135 | |
| 127550 | |
| 178500 |