| URN | urn:agi-llid:7056 |
|---|---|
| Name | THBD |
| Description | thrombomodulin |
| Connectivity | 255 |
| Notes | The protein encoded by this intronless gene is an endothelial-specific type I membrane receptor that binds thrombin. This binding results in the activation of protein C, which degrades clotting factors Va and VIIIa and reduces the amount of thrombin generated. Mutations in this gene are a cause of thromboembolic disease, also known as inherited thrombophilia. [provided by RefSeq] |
| Swiss-Prot Accession | P07204 |
|---|---|
| P15306 | |
| Q543W3 | |
| Q8BJB5 | |
| O35370 | |
| P97883 | |
| Q792T4 |
| Unigene ID | Hs.2030 |
|---|---|
| Mm.24096 | |
| Rn.88295 |
| KEGG ID | mmu:21824 |
|---|
| Swiss-Prot ID | TRBM_HUMAN |
|---|---|
| TRBM_MOUSE | |
| O35370_RAT | |
| Q543W3_MOUSE |
| Cell Localization | Plasma membrane |
|---|
| GO ID | 0005509 |
|---|---|
| 0005515 | |
| 0004888 | |
| 0007596 | |
| 0009790 | |
| 0007565 | |
| 0010165 | |
| 0051591 | |
| 0032496 | |
| 0005615 | |
| 0005887 | |
| 0005886 | |
| 0005488 | |
| 0004872 | |
| 0050819 | |
| 0016021 | |
| 0016020 | |
| 0003674 | |
| 0009986 |
| Pathway | VDR Targets |
|---|
| IPI ID | IPI00010737 |
|---|---|
| IPI00129423 | |
| IPI00208472 |
| Ariadne Ontology | Scavenger receptor |
|---|
| Mouse chromosome position | 2 84.0 cM |
|---|
| GO Molecular Function | molecular_function |
|---|---|
| binding | |
| protein binding | |
| calcium ion binding | |
| receptor activity | |
| transmembrane receptor activity |
| Homologene ID | 308 |
|---|
| Hugo ID | 11784 |
|---|
| GO Cellular Component | cell surface |
|---|---|
| membrane | |
| plasma membrane | |
| integral to membrane | |
| integral to plasma membrane | |
| extracellular space |
| MGI ID | 98736 |
|---|
| Human chromosome position | 20p11.2 |
|---|
| GO Biological Process | negative regulation of coagulation |
|---|---|
| blood coagulation | |
| embryonic development | |
| female pregnancy | |
| response to lipopolysaccharide | |
| response to X-ray | |
| response to cAMP |
| Rat chromosome position | 3q41 |
|---|
| Group | Scavenger receptor |
|---|---|
| cell surface | |
| membrane | |
| plasma membrane | |
| integral to membrane | |
| integral to plasma membrane | |
| extracellular space | |
| molecular_function | |
| binding | |
| protein binding | |
| calcium ion binding | |
| receptor activity | |
| transmembrane receptor activity | |
| negative regulation of coagulation | |
| blood coagulation | |
| embryonic development | |
| female pregnancy | |
| response to lipopolysaccharide | |
| response to X-ray | |
| response to cAMP |
| RGD ID | 621299 |
|---|
| LocusLink ID | 7056 |
|---|---|
| 21824 | |
| 83580 |
| Alias | TM |
|---|---|
| THRM | |
| CD141 | |
| thrombomodulin | |
| fetomodulin | |
| CD141 antigen | |
| OTTHUMP00000030415 | |
| AI385582 | |
| RP23-70N3.2 | |
| snoRNA MBII-339 | |
| OTTMUSP00000016721 | |
| thrombomdulin | |
| THBD |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 188040 |
|---|