| URN | urn:agi-llid:8841 |
|---|---|
| Name | HDAC3 |
| Description | histone deacetylase 3 |
| Connectivity | 234 |
| Notes | Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. |
| Swiss-Prot Accession | O15379 |
|---|---|
| Q9H368 | |
| Q3UM33 | |
| Q9JM08 | |
| O88895 | |
| Q9JLX5 | |
| Q6P6W3 |
| Unigene ID | Hs.519632 |
|---|---|
| Mm.20521 | |
| Rn.17284 |
| KEGG ID | hsa:8841 |
|---|---|
| mmu:15183 | |
| rno:84578 |
| EC Number | 3.5.1.98 |
|---|
| Swiss-Prot ID | HDAC3_HUMAN |
|---|---|
| HDAC3_RAT | |
| Q3UM33_MOUSE | |
| Q9JM08_MOUSE |
| Cell Localization | Nucleus |
|---|
| GO ID | 0003677 |
|---|---|
| 0004407 | |
| 0016787 | |
| 0008134 | |
| 0006916 | |
| 0016568 | |
| 0016575 | |
| 0007346 | |
| 0006355 | |
| 0006350 | |
| 0005737 | |
| 0000118 | |
| 0005634 | |
| 0005515 | |
| 0042493 | |
| 0000785 |
| Pathway | PPARG Targets |
|---|---|
| VDR Targets |
| IPI ID | IPI00006187 |
|---|---|
| IPI00217965 | |
| IPI00228758 | |
| IPI00135456 | |
| IPI00421548 | |
| IPI00780533 |
| Ariadne Ontology | Chromatin remodeling |
|---|
| Mouse chromosome position | 18 17.0 cM |
|---|
| GO Molecular Function | protein binding |
|---|---|
| DNA binding | |
| transcription factor binding | |
| hydrolase activity | |
| histone deacetylase activity |
| Homologene ID | 48250 |
|---|
| Hugo ID | 4854 |
|---|
| GO Cellular Component | cytoplasm |
|---|---|
| nucleus | |
| histone deacetylase complex | |
| chromatin |
| MGI ID | 1343091 |
|---|
| Human chromosome position | 5q31 |
|---|
| GO Biological Process | anti-apoptosis |
|---|---|
| regulation of mitotic cell cycle | |
| regulation of transcription, DNA-dependent | |
| chromatin modification | |
| histone deacetylation | |
| transcription | |
| response to drug |
| Rat chromosome position | 18p11 |
|---|
| Group | Chromatin remodeling |
|---|---|
| cytoplasm | |
| nucleus | |
| histone deacetylase complex | |
| chromatin | |
| protein binding | |
| DNA binding | |
| transcription factor binding | |
| hydrolase activity | |
| histone deacetylase activity | |
| anti-apoptosis | |
| regulation of mitotic cell cycle | |
| regulation of transcription, DNA-dependent | |
| chromatin modification | |
| histone deacetylation | |
| transcription | |
| response to drug |
| RGD ID | 619977 |
|---|
| LocusLink ID | 8841 |
|---|---|
| 15183 | |
| 84578 |
| Alias | HD3 |
|---|---|
| RPD3 | |
| RPD3-2 | |
| histone deacetylase 3 | |
| AW537363 | |
| OTTMUSP00000018789 | |
| HDAC3 | |
| histone deacetylase III | |
| RPD3 II | |
| RPD3-2s |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 605166 |
|---|