| URN | urn:agi-llid:1581 |
|---|---|
| Name | CYP7A1 |
| Description | cytochrome P450, family 7, subfamily A, polypeptide 1 |
| Connectivity | 201 |
| Notes | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway in the liver, which converts cholesterol to bile acids. This reaction is the rate limiting step and the major site of regulation of bile acid synthesis, which is the primary mechanism for the removal of cholesterol from the body. |
| Swiss-Prot Accession | P22680 |
|---|---|
| Q8BFR7 | |
| Q64505 | |
| P18125 |
| Unigene ID | Hs.1644 |
|---|---|
| Mm.57029 | |
| Rn.10737 |
| KEGG ID | hsa:1581 |
|---|---|
| mmu:13122 | |
| rno:25428 |
| EC Number | 1.14.13.17 |
|---|
| Swiss-Prot ID | CP7A1_HUMAN |
|---|---|
| CP7A1_RAT | |
| Q8BFR7_MOUSE |
| Cell Localization | Endoplasmic reticulum |
|---|
| GO ID | 0008123 |
|---|---|
| 0009055 | |
| 0020037 | |
| 0046872 | |
| 0004497 | |
| 0006707 | |
| 0006629 | |
| 0055114 | |
| 0008202 | |
| 0005783 | |
| 0005789 | |
| 0016020 | |
| 0005792 | |
| 0005506 | |
| 0016491 | |
| 0008203 | |
| 0006699 | |
| 0016021 |
| Pathway | HepG2 Extracts |
|---|---|
| Figure 3 CAR 2009 | |
| FXR Targets | |
| Toxicology Array | |
| New Pathway | |
| PPARalpha Pathway | |
| PPARalpha Targets | |
| VDR Targets |
| IPI ID | IPI00305356 |
|---|---|
| IPI00135398 | |
| IPI00307883 | |
| IPI00188937 |
| Ariadne Ontology | Bile acid metabolism |
|---|---|
| Cholesterol/isoprenoid metabolism |
| Mouse chromosome position | 4 A1 |
|---|
| GO Molecular Function | electron carrier activity |
|---|---|
| metal ion binding | |
| iron ion binding | |
| heme binding | |
| oxidoreductase activity | |
| monooxygenase activity | |
| cholesterol 7-alpha-monooxygenase activity |
| Homologene ID | 30987 |
|---|
| Hugo ID | 2651 |
|---|
| GO Cellular Component | membrane |
|---|---|
| microsome | |
| endoplasmic reticulum membrane | |
| endoplasmic reticulum |
| MGI ID | 106091 |
|---|
| Human chromosome position | 8q11-q12 |
|---|
| GO Biological Process | cholesterol metabolic process |
|---|---|
| cholesterol catabolic process | |
| steroid metabolic process | |
| bile acid biosynthetic process | |
| oxidation reduction | |
| lipid metabolic process |
| Rat chromosome position | 5q12 |
|---|
| Group | Bile acid metabolism |
|---|---|
| Cholesterol/isoprenoid metabolism | |
| membrane | |
| microsome | |
| endoplasmic reticulum membrane | |
| endoplasmic reticulum | |
| electron carrier activity | |
| metal ion binding | |
| iron ion binding | |
| heme binding | |
| oxidoreductase activity | |
| monooxygenase activity | |
| cholesterol 7-alpha-monooxygenase activity | |
| cholesterol metabolic process | |
| cholesterol catabolic process | |
| steroid metabolic process | |
| bile acid biosynthetic process | |
| oxidation reduction | |
| lipid metabolic process | |
| Liver Lipid Transport |
| RGD ID | 2482 |
|---|
| LocusLink ID | 1581 |
|---|---|
| 13122 | |
| 25428 |
| Alias | CP7A |
|---|---|
| CYP7 | |
| MGC126826 | |
| MGC138389 | |
| cytochrome P450, family 7, subfamily A, polypeptide 1 | |
| cholesterol 7-alpha-hydroxylase | |
| cholesterol 7 alpha-monooxygenase | |
| cytochrome P450, subfamily VIIA (cholesterol 7 alpha-monooxygenase), polypeptide 1 | |
| RP23-89L15.2 | |
| OTTMUSP00000004700 | |
| cytochrome P450, 7a1 | |
| cholesterol 7 alpha hydroxylase | |
| CHAP | |
| CYP7S1 | |
| cholesterol 7-alpha hydroxylase | |
| Cytochrom P450 (cholesterol hydroxylase 7 alpha) | |
| cytochrome P450 (cholesterol hydroxylase 7 alpha) | |
| Cholesterol 7-alpha-monooxygenase | |
| Cyp7a1 | |
| CYPVII | |
| cytochrome P450, family 7, subfamily A, polypeptide | |
| cytochrome P450, subfamily VIIA (cholesterol 7 alpha-monooxygenase), polype | |
| cytochrome P450, subfamily VIIA, polypeptide 1 | |
| cytochrome P450, subfamily VIIA, polypeptide I | |
| Cyp7a I | |
| CYP7S I | |
| Cytochrome P450 7A I | |
| Cytochrome P450 7A1 | |
| cholesterol hydroxylase 7 alpha |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 118455 |
|---|