| URN | urn:agi-llid:6678 |
|---|---|
| Name | SPARC |
| Description | secreted protein, acidic, cysteine-rich (osteonectin) |
| Connectivity | 299 |
| Notes | Secreted protein acidic and rich in cysteine/osteonectin/BM40, or SPARC, is a matrix-associated protein that elicits changes in cell shape, inhibits cell-cycle progression, and influences the synthesis of extracellular matrix (ECM) (Bradshaw et al., 2003 [PubMed 12721366]).[supplied by OMIM] |
| Swiss-Prot Accession | P09486 |
|---|---|
| Q6IBK4 | |
| Q6QE20 | |
| P07214 | |
| Q5NCU5 | |
| Q3TXI6 | |
| P16975 |
| Unigene ID | Hs.111779 |
|---|---|
| Hs.708558 | |
| Mm.291442 | |
| Rn.98989 |
| KEGG ID | hsa:6678 |
|---|---|
| mmu:20692 | |
| rno:24791 |
| Swiss-Prot ID | SPRC_HUMAN |
|---|---|
| SPRC_MOUSE | |
| SPRC_RAT | |
| Q6IBK4_HUMAN | |
| Q5NCU5_MOUSE |
| Cell Localization | Extracellular |
|---|
| GO ID | 0005509 |
|---|---|
| 0005518 | |
| 0005507 | |
| 0001503 | |
| 0042127 | |
| 0007165 | |
| 0007169 | |
| 0005604 | |
| 0005576 | |
| 0031093 | |
| 0050840 | |
| 0031012 | |
| 0005578 | |
| 0007507 | |
| 0048839 | |
| 0030324 | |
| 0033591 | |
| 0051591 | |
| 0046686 | |
| 0051592 | |
| 0034097 | |
| 0045471 | |
| 0051384 | |
| 0009629 | |
| 0010288 | |
| 0032496 | |
| 0043434 | |
| 0042060 | |
| 0005737 | |
| 0005615 | |
| 0005622 | |
| 0031988 | |
| 0005634 |
| Pathway | VDR Targets |
|---|
| IPI ID | IPI00014572 |
|---|---|
| IPI00847359 | |
| IPI00126343 | |
| IPI00650029 | |
| IPI00649246 | |
| IPI00189424 |
| Ariadne Ontology | Extracellular matrix polymerization |
|---|
| Mouse chromosome position | 11 29.9 cM |
|---|
| GO Molecular Function | extracellular matrix binding |
|---|---|
| calcium ion binding | |
| copper ion binding | |
| collagen binding |
| Homologene ID | 31132 |
|---|
| Hugo ID | 11219 |
|---|
| GO Cellular Component | extracellular region |
|---|---|
| intracellular | |
| cytoplasm | |
| platelet alpha granule lumen | |
| nucleus | |
| extracellular space | |
| extracellular matrix | |
| proteinaceous extracellular matrix | |
| basement membrane | |
| membrane-bounded vesicle |
| MGI ID | 98373 |
|---|
| Human chromosome position | 5q31.3-q32 |
|---|
| GO Biological Process | signal transduction |
|---|---|
| regulation of cell proliferation | |
| transmembrane receptor protein tyrosine kinase signaling pathway | |
| ossification | |
| inner ear development | |
| heart development | |
| lung development | |
| response to lipopolysaccharide | |
| response to gravity | |
| response to cytokine stimulus | |
| response to peptide hormone stimulus | |
| response to glucocorticoid stimulus | |
| response to lead ion | |
| response to cadmium ion | |
| response to calcium ion | |
| response to L-ascorbic acid | |
| response to cAMP | |
| response to ethanol | |
| wound healing |
| Rat chromosome position | 10q22 |
|---|
| Group | Extracellular matrix polymerization |
|---|---|
| extracellular region | |
| intracellular | |
| cytoplasm | |
| platelet alpha granule lumen | |
| nucleus | |
| extracellular space | |
| extracellular matrix | |
| proteinaceous extracellular matrix | |
| basement membrane | |
| membrane-bounded vesicle | |
| extracellular matrix binding | |
| calcium ion binding | |
| copper ion binding | |
| collagen binding | |
| signal transduction | |
| regulation of cell proliferation | |
| transmembrane receptor protein tyrosine kinase signaling pathway | |
| ossification | |
| inner ear development | |
| heart development | |
| lung development | |
| response to lipopolysaccharide | |
| response to gravity | |
| response to cytokine stimulus | |
| response to peptide hormone stimulus | |
| response to glucocorticoid stimulus | |
| response to lead ion | |
| response to cadmium ion | |
| response to calcium ion | |
| response to L-ascorbic acid | |
| response to cAMP | |
| response to ethanol | |
| wound healing |
| RGD ID | 3742 |
|---|
| LocusLink ID | 6678 |
|---|---|
| 20692 | |
| 24791 |
| Alias | ON |
|---|---|
| secreted protein, acidic, cysteine-rich | |
| osteonectin | |
| cysteine-rich protein | |
| BM-40 | |
| AA517111 | |
| RP23-465I4.1 | |
| secreted acidic cysteine rich glycoprotein | |
| OTTMUSP00000005868 | |
| secreted protein, acidic, cysteine-rich (osteonectin) | |
| Secreted acidic cystein-rich glycoprotein (osteonectin) | |
| Secreted acidic cystein-rich glycoprotein (osteonectin) | |
| Secreted protein acidic and rich in cysteine | |
| SPARC | |
| Basement membrane protein BM-40 | |
| Osteonectin (secreted protein, acidic, cysteine-rich) |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 182120 |
|---|