| URN | urn:agi-llid:4982 |
|---|---|
| Name | TNFRSF11B |
| Description | tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) |
| Connectivity | 390 |
| Notes | The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. |
| Swiss-Prot Accession | O00300 |
|---|---|
| O08712 | |
| Q3UK97 | |
| Q6PI12 | |
| O08727 |
| Unigene ID | Hs.81791 |
|---|---|
| Mm.15383 | |
| Rn.202973 |
| KEGG ID | hsa:4982 |
|---|---|
| mmu:18383 | |
| rno:25341 |
| Swiss-Prot ID | TR11B_HUMAN |
|---|---|
| TR11B_MOUSE | |
| TR11B_RAT | |
| Q3UK97_MOUSE |
| Cell Localization | Plasma membrane |
|---|
| GO ID | 0005125 |
|---|---|
| 0005515 | |
| 0004872 | |
| 0006915 | |
| 0042489 | |
| 0007165 | |
| 0001501 | |
| 0005576 | |
| 0005578 | |
| 0030198 | |
| 0045779 | |
| 0045671 | |
| 0046685 | |
| 0042493 | |
| 0043627 | |
| 0010035 | |
| 0032026 | |
| 0007584 | |
| 0005615 |
| Pathway | CVD and receptors (all) |
|---|---|
| CVD and receptors (all) + Ligands | |
| PPARG Targets | |
| VDR Targets |
| IPI ID | IPI00298362 |
|---|---|
| IPI00115498 | |
| IPI00195514 |
| Ariadne Ontology | TNFR |
|---|
| Mouse chromosome position | 15 D1 |
|---|
| GO Molecular Function | protein binding |
|---|---|
| cytokine activity | |
| receptor activity |
| Homologene ID | 1912 |
|---|
| Hugo ID | 11909 |
|---|
| GO Cellular Component | extracellular region |
|---|---|
| extracellular space | |
| proteinaceous extracellular matrix |
| MGI ID | 109587 |
|---|
| Human chromosome position | 8q24 |
|---|
| GO Biological Process | negative regulation of osteoclast differentiation |
|---|---|
| negative regulation of odontogenesis of dentine-containing tooth | |
| negative regulation of bone resorption | |
| signal transduction | |
| apoptosis | |
| extracellular matrix organization | |
| skeletal system development | |
| response to drug | |
| response to inorganic substance | |
| response to nutrient | |
| response to estrogen stimulus | |
| response to arsenic | |
| response to magnesium ion |
| Rat chromosome position | 7q31 |
|---|
| Group | TNFR |
|---|---|
| extracellular region | |
| extracellular space | |
| proteinaceous extracellular matrix | |
| protein binding | |
| cytokine activity | |
| receptor activity | |
| negative regulation of osteoclast differentiation | |
| negative regulation of odontogenesis of dentine-containing tooth | |
| negative regulation of bone resorption | |
| signal transduction | |
| apoptosis | |
| extracellular matrix organization | |
| skeletal system development | |
| response to drug | |
| response to inorganic substance | |
| response to nutrient | |
| response to estrogen stimulus | |
| response to arsenic | |
| response to magnesium ion |
| RGD ID | 619802 |
|---|
| LocusLink ID | 4982 |
|---|---|
| 18383 | |
| 25341 |
| Alias | OPG |
|---|---|
| TR1 | |
| OCIF | |
| MGC29565 | |
| osteoprotegerin | |
| osteoclastogenesis inhibitory factor | |
| tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) | |
| MGC93568 | |
| tumor necrosis factor receptor superfamily, member 11b | |
| Tnfrsf11b | |
| TR I | |
| Tnfrsf11b-good | |
| tumor necrosis factor receptor superfamily member 11b |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 602643 |
|---|---|
| 239000 |