| URN | urn:agi-llid:912 |
|---|---|
| Name | CD1D |
| Description | CD1d molecule |
| Connectivity | 171 |
| Notes | This gene encodes a divergent member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail. [provided by RefSeq] |
| Swiss-Prot Accession | P15813 |
|---|---|
| P11609 | |
| Q7TMK5 | |
| P11610 | |
| Q6PG97 | |
| Q80XA2 | |
| Q63493 | |
| Q9R1S6 |
| Unigene ID | Hs.1799 |
|---|---|
| Mm.1894 | |
| Mm.389465 | |
| Rn.11120 |
| KEGG ID | hsa:912 |
|---|---|
| mmu:12479 | |
| mmu:12480 | |
| rno:25109 |
| Swiss-Prot ID | CD1D1_MOUSE |
|---|---|
| CD1D2_MOUSE | |
| CD1D_HUMAN | |
| CD1D_RAT |
| GO ID | 0030881 |
|---|---|
| 0030884 | |
| 0046982 | |
| 0004872 | |
| 0045058 | |
| 0019882 | |
| 0048006 | |
| 0016045 | |
| 0044419 | |
| 0045089 | |
| 0042612 | |
| 0005768 | |
| 0010008 | |
| 0005887 | |
| 0005765 | |
| 0005886 | |
| 0030883 | |
| 0005515 | |
| 0048007 | |
| 0006955 | |
| 0045087 | |
| 0051135 | |
| 0051138 | |
| 0001916 | |
| 0045078 | |
| 0045086 | |
| 0045404 | |
| 0045059 | |
| 0050776 | |
| 0005769 | |
| 0009897 | |
| 0016021 | |
| 0005770 | |
| 0005764 | |
| 0016020 |
| Pathway | VDR Targets |
|---|
| IPI ID | IPI00013435 |
|---|---|
| IPI00320065 | |
| IPI00115736 | |
| IPI00403351 | |
| IPI00857369 | |
| IPI00409409 | |
| IPI00209184 | |
| IPI00777872 |
| Mouse chromosome position | 3 48.0 cM |
|---|
| GO Molecular Function | protein binding |
|---|---|
| exogenous lipid antigen binding | |
| endogenous lipid antigen binding | |
| beta-2-microglobulin binding | |
| protein heterodimerization activity | |
| receptor activity |
| Hugo ID | 1637 |
|---|
| GO Cellular Component | membrane |
|---|---|
| external side of plasma membrane | |
| endosome | |
| endosome membrane | |
| early endosome | |
| late endosome | |
| lysosomal membrane | |
| lysosome | |
| plasma membrane | |
| integral to membrane | |
| integral to plasma membrane | |
| MHC class I protein complex |
| MGI ID | 107674 |
|---|---|
| 107675 |
| Human chromosome position | 1q22-q23 |
|---|
| GO Biological Process | positive regulation of T cell mediated cytotoxicity |
|---|---|
| positive regulation of NK T cell differentiation | |
| positive regulation of NK T cell activation | |
| positive regulation of interleukin-4 biosynthetic process | |
| positive regulation of interleukin-2 biosynthetic process | |
| positive regulation of interferon-gamma biosynthetic process | |
| positive regulation of innate immune response | |
| regulation of immune response | |
| T cell selection | |
| positive thymic T cell selection | |
| antigen processing and presentation | |
| immune response | |
| antigen processing and presentation, endogenous lipid antigen via MHC class Ib | |
| antigen processing and presentation, exogenous lipid antigen via MHC class Ib | |
| innate immune response | |
| interspecies interaction between organisms | |
| detection of bacterium |
| Rat chromosome position | 2q34 |
|---|
| Group | membrane |
|---|---|
| external side of plasma membrane | |
| endosome | |
| endosome membrane | |
| early endosome | |
| late endosome | |
| lysosomal membrane | |
| lysosome | |
| plasma membrane | |
| integral to membrane | |
| integral to plasma membrane | |
| MHC class I protein complex | |
| protein binding | |
| exogenous lipid antigen binding | |
| endogenous lipid antigen binding | |
| beta-2-microglobulin binding | |
| protein heterodimerization activity | |
| receptor activity | |
| positive regulation of T cell mediated cytotoxicity | |
| positive regulation of NK T cell differentiation | |
| positive regulation of NK T cell activation | |
| positive regulation of interleukin-4 biosynthetic process | |
| positive regulation of interleukin-2 biosynthetic process | |
| positive regulation of interferon-gamma biosynthetic process | |
| positive regulation of innate immune response | |
| regulation of immune response | |
| T cell selection | |
| positive thymic T cell selection | |
| antigen processing and presentation | |
| immune response | |
| antigen processing and presentation, endogenous lipid antigen via MHC class Ib | |
| antigen processing and presentation, exogenous lipid antigen via MHC class Ib | |
| innate immune response | |
| interspecies interaction between organisms | |
| detection of bacterium |
| RGD ID | 2296 |
|---|
| LocusLink ID | 912 |
|---|---|
| 12479 | |
| 12480 | |
| 25109 |
| Alias | R3 |
|---|---|
| CD1A | |
| MGC34622 | |
| CD1D antigen | |
| OTTHUMP00000024053 | |
| thymocyte antigen CD1D | |
| CD1D antigen, d polypeptide | |
| T-cell surface glycoprotein CD1d | |
| differentiation antigen CD1-alpha-3 | |
| HMC class I antigen-like glycoprotein CD1D | |
| Cd1d | |
| CD1.1 | |
| Ly-38 | |
| AI747460 | |
| CD1d1 antigen | |
| OTTMUSP00000029117 | |
| Cd1b | |
| CD1.2 | |
| CD1d2 antigen | |
| T-cell surface glycoprotein CD1d2 | |
| Cd1 | |
| CD1d1 molecule | |
| CD1d1 | |
| T-cell surface glycoprotein CD1d precursor | |
| CD1D antigen, also localized to RNO7q32 but is presumably on chromosome | |
| R3G I | |
| R3G1 | |
| Cd1d I | |
| Cd1d2 | |
| CD11_MOUSE | |
| T-cell surface glycoprotein CD1d1 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 188410 |
|---|