| URN | urn:agi-llid:240 |
|---|---|
| Name | ALOX5 |
| Description | arachidonate 5-lipoxygenase |
| Connectivity | 324 |
| Notes | This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined. |
| Swiss-Prot Accession | P09917 |
|---|---|
| Q59H13 | |
| Q3TB75 | |
| P48999 | |
| Q3TBK8 | |
| Q3TC68 | |
| Q810M3 | |
| P12527 |
| Unigene ID | Hs.89499 |
|---|---|
| Mm.41072 | |
| Rn.9662 |
| KEGG ID | hsa:240 |
|---|---|
| rno:25290 | |
| mmu:11689 |
| EC Number | 1.13.11.34 |
|---|
| Swiss-Prot ID | LOX5_HUMAN |
|---|---|
| LOX5_RAT | |
| Q3TB75_MOUSE |
| Cell Localization | Plasma membrane |
|---|
| GO ID | 0004051 |
|---|---|
| 0005509 | |
| 0005506 | |
| 0016165 | |
| 0016491 | |
| 0005515 | |
| 0006954 | |
| 0019370 | |
| 0055114 | |
| 0005737 | |
| 0016020 | |
| 0005634 | |
| 0046872 | |
| 0016702 | |
| 0006691 | |
| 0019369 | |
| 0019372 | |
| 0045907 | |
| 0007584 | |
| 0030425 | |
| 0005635 | |
| 0042383 | |
| 0005625 |
| Pathway | NIH Omega 3 |
|---|---|
| VDR Targets |
| IPI ID | IPI00218916 |
|---|---|
| IPI00418599 | |
| IPI00115652 | |
| IPI00652353 | |
| IPI00194785 |
| Ariadne Ontology | Leukotriene synthesis |
|---|
| Mouse chromosome position | 6 53.2 cM |
|---|
| GO Molecular Function | protein binding |
|---|---|
| metal ion binding | |
| calcium ion binding | |
| iron ion binding | |
| oxidoreductase activity | |
| oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen | |
| arachidonate 5-lipoxygenase activity | |
| lipoxygenase activity |
| Homologene ID | 561 |
|---|
| Hugo ID | 435 |
|---|
| GO Cellular Component | membrane |
|---|---|
| soluble fraction | |
| dendrite | |
| nuclear envelope | |
| cytoplasm | |
| nucleus | |
| sarcolemma |
| MGI ID | 87999 |
|---|
| Human chromosome position | 10q11.2 |
|---|
| GO Biological Process | positive regulation of vasoconstriction |
|---|---|
| leukotriene metabolic process | |
| leukotriene biosynthetic process | |
| lipoxygenase pathway | |
| arachidonic acid metabolic process | |
| oxidation reduction | |
| response to nutrient | |
| inflammatory response |
| Rat chromosome position | 4q42 |
|---|
| Group | Leukotriene synthesis |
|---|---|
| membrane | |
| soluble fraction | |
| dendrite | |
| nuclear envelope | |
| cytoplasm | |
| nucleus | |
| sarcolemma | |
| protein binding | |
| metal ion binding | |
| calcium ion binding | |
| iron ion binding | |
| oxidoreductase activity | |
| oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen | |
| arachidonate 5-lipoxygenase activity | |
| lipoxygenase activity | |
| positive regulation of vasoconstriction | |
| leukotriene metabolic process | |
| leukotriene biosynthetic process | |
| lipoxygenase pathway | |
| arachidonic acid metabolic process | |
| oxidation reduction | |
| response to nutrient | |
| inflammatory response |
| RGD ID | 2096 |
|---|
| LocusLink ID | 240 |
|---|---|
| 11689 | |
| 25290 |
| Alias | 5-LO |
|---|---|
| 5LPG | |
| LOG5 | |
| 5-LOX | |
| MGC163204 | |
| RP11-67C2.3 | |
| arachidonate 5-lipoxygenase | |
| OTTHUMP00000019502 | |
| leukotriene A4 synthase | |
| arachidonic acid 5-lipoxygenase | |
| 5LO | |
| 5LX | |
| AI850497 | |
| F730011J02 | |
| LOX5A | |
| 5-lipoxygenase | |
| 5 - Lipoxygenase | |
| ALOX5 | |
| arachidonic 5-lipoxygenase | |
| arachidonate 5-LOX | |
| 5D-lipoxygenases | |
| arachidonic 5-lipoxygenases | |
| arachidonic acid 5-lipoxygenases | |
| C-5-lipoxygenases | |
| delta5-lipoxygenases | |
| 5D-lipoxygenase | |
| hypothetical protein F730011J02 | |
| 5(LX) | |
| 5-LX | |
| 5 LX | |
| 5 LO |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 152390 |
|---|---|
| 600807 |