| URN | urn:agi-llid:5972 |
|---|---|
| Name | REN |
| Description | renin |
| Connectivity | 703 |
| Notes | Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia. |
| Swiss-Prot Accession | P00797 |
|---|---|
| Q6FI38 | |
| Q15296 | |
| Q9UQK5 | |
| P06281 | |
| Q9R259 | |
| P08424 | |
| Q9JIE2 | |
| Q9R258 |
| Unigene ID | Hs.3210 |
|---|---|
| Mm.220955 | |
| Rn.9831 |
| KEGG ID | hsa:5972 |
|---|---|
| mmu:19701 | |
| rno:24715 |
| EC Number | 3.4.23.15 |
|---|
| Swiss-Prot ID | RENI1_MOUSE |
|---|---|
| RENI_HUMAN | |
| RENI_RAT | |
| Q6FI38_HUMAN |
| GO ID | 0004190 |
|---|---|
| 0008233 | |
| 0005102 | |
| 0002003 | |
| 0001822 | |
| 0006508 | |
| 0043408 | |
| 0008217 | |
| 0005737 | |
| 0005576 | |
| 0005615 | |
| 0043231 | |
| 0016020 | |
| 0016787 | |
| 0048469 | |
| 0042756 | |
| 0008065 | |
| 0009755 | |
| 0002016 | |
| 0005159 | |
| 0044444 | |
| 0004194 | |
| 0004195 |
| Pathway | Figure 3 CAR 2009 |
|---|---|
| PPARG Targets | |
| VDR Targets |
| IPI ID | IPI00019644 |
|---|---|
| IPI00552207 | |
| IPI00872010 | |
| IPI00121828 | |
| IPI00876305 | |
| IPI00831677 | |
| IPI00211210 |
| Mouse chromosome position | 1 69.9 cM |
|---|
| GO Molecular Function | receptor binding |
|---|---|
| insulin-like growth factor receptor binding | |
| hydrolase activity | |
| peptidase activity | |
| aspartic-type endopeptidase activity |
| Hugo ID | 9958 |
|---|
| GO Cellular Component | extracellular region |
|---|---|
| membrane | |
| cytoplasm | |
| cytoplasmic part | |
| intracellular membrane-bounded organelle | |
| extracellular space |
| MGI ID | 97898 |
|---|
| Human chromosome position | 1q32 |
|---|
| GO Biological Process | regulation of MAPKKK cascade |
|---|---|
| hormone-mediated signaling | |
| angiotensin maturation | |
| regulation of blood pressure | |
| regulation of blood volume by renin-angiotensin | |
| cell maturation | |
| establishment of blood-nerve barrier | |
| kidney development | |
| proteolysis | |
| drinking behavior |
| Rat chromosome position | 13q13 |
|---|
| Group | extracellular region |
|---|---|
| membrane | |
| cytoplasm | |
| cytoplasmic part | |
| intracellular membrane-bounded organelle | |
| extracellular space | |
| receptor binding | |
| insulin-like growth factor receptor binding | |
| hydrolase activity | |
| peptidase activity | |
| aspartic-type endopeptidase activity | |
| regulation of MAPKKK cascade | |
| hormone-mediated signaling | |
| angiotensin maturation | |
| regulation of blood pressure | |
| regulation of blood volume by renin-angiotensin | |
| cell maturation | |
| establishment of blood-nerve barrier | |
| kidney development | |
| proteolysis | |
| drinking behavior |
| RGD ID | 3554 |
|---|
| LocusLink ID | 5972 |
|---|---|
| 19701 | |
| 24715 |
| Alias | FLJ10761 |
|---|---|
| renin | |
| OTTHUMP00000034311 | |
| angiotensinogenase | |
| renin precursor, renal | |
| angiotensin-forming enzyme | |
| Ren | |
| Rnr | |
| Rn-1 | |
| Ren-1 | |
| Ren-A | |
| Ren1c | |
| Ren1d | |
| D19352 | |
| renin 1 structural | |
| renin b | |
| aspartyl-protease | |
| OTTMUSP00000024128 | |
| Ren1 | |
| RENAA | |
| RATRENAA | |
| renin (Ren-1-d) | |
| renin 1 | |
| Ren I | |
| hRen1 | |
| hRen | |
| Rn I | |
| LOC100038824 | |
| LOC547363 | |
| angiotensinogenase precursor | |
| angiotensin-forming enzyme precursor | |
| renin 1s | |
| similar to renin |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 179820 |
|---|---|
| 267430 |