| URN | urn:agi-llid:1559 |
|---|---|
| Name | CYP2C9 |
| Description | cytochrome P450, family 2, subfamily C, polypeptide 9 |
| Connectivity | 126 |
| Notes | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by rifampin. The enzyme is known to metabolize many xenobiotics, including phenytoin, tolbutamide, ibuprofen and S-warfarin. Studies identifying individuals who are poor metabolizers of phenytoin and tolbutamide suggest that this gene is polymorphic. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. [provided by RefSeq] |
| Swiss-Prot Accession | P11712 |
|---|---|
| Q5VX92 | |
| Q5EDC5 | |
| Q6IRV8 | |
| Q8WW80 | |
| Q9UEH3 | |
| Q9UQ59 | |
| P08683 |
| Unigene ID | Hs.282624 |
|---|---|
| Rn.10870 |
| KEGG ID | hsa:1559 |
|---|---|
| rno:29277 |
| EC Number | 1.14.14.1 |
|---|---|
| 1.14.13.48 | |
| 1.14.13.49 | |
| 1.14.13.80 |
| Swiss-Prot ID | CP2C9_HUMAN |
|---|---|
| CP2CB_RAT | |
| Q5VX92_HUMAN |
| Cell Localization | Plasma membrane |
|---|
| GO ID | 0018675 |
|---|---|
| 0018676 | |
| 0033767 | |
| 0009055 | |
| 0020037 | |
| 0046872 | |
| 0004497 | |
| 0055114 | |
| 0005783 | |
| 0005789 | |
| 0016020 | |
| 0005792 | |
| 0070330 | |
| 0008390 | |
| 0006805 |
| Pathway | Toxicology Array |
|---|---|
| VDR Targets |
| IPI ID | IPI00007219 |
|---|---|
| IPI00327781 | |
| IPI00780962 |
| Ariadne Ontology | Leukotriene synthesis |
|---|
| GO Molecular Function | electron carrier activity |
|---|---|
| metal ion binding | |
| heme binding | |
| monooxygenase activity | |
| 4-hydroxyacetophenone monooxygenase activity | |
| (S)-limonene 6-monooxygenase activity | |
| (S)-limonene 7-monooxygenase activity | |
| aromatase activity | |
| testosterone 16-alpha-hydroxylase activity |
| Homologene ID | 110445 |
|---|
| Hugo ID | 2623 |
|---|
| GO Cellular Component | membrane |
|---|---|
| microsome | |
| endoplasmic reticulum membrane | |
| endoplasmic reticulum |
| Human chromosome position | 10q24 |
|---|
| GO Biological Process | xenobiotic metabolic process |
|---|---|
| oxidation reduction |
| Rat chromosome position | 1q53 |
|---|
| Group | Leukotriene synthesis |
|---|---|
| membrane | |
| microsome | |
| endoplasmic reticulum membrane | |
| endoplasmic reticulum | |
| electron carrier activity | |
| metal ion binding | |
| heme binding | |
| monooxygenase activity | |
| 4-hydroxyacetophenone monooxygenase activity | |
| (S)-limonene 6-monooxygenase activity | |
| (S)-limonene 7-monooxygenase activity | |
| aromatase activity | |
| testosterone 16-alpha-hydroxylase activity | |
| xenobiotic metabolic process | |
| oxidation reduction |
| RGD ID | 2469 |
|---|
| LocusLink ID | 1559 |
|---|---|
| 29277 |
| Alias | CPC9 |
|---|---|
| CYP2C | |
| CYP2C10 | |
| MGC88320 | |
| P450IIC9 | |
| MGC149605 | |
| cytochrome P450, family 2, subfamily C, polypeptide 9 | |
| OTTHUMP00000020135 | |
| cytochrome p4502C9 | |
| microsomal monooxygenase | |
| xenobiotic monooxygenase | |
| flavoprotein-linked monooxygenase | |
| cytochrome P-450 S-mephenytoin 4-hydroxylase | |
| cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 9 | |
| cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 10 | |
| CYP2CII | |
| cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase) | |
| cytochrome P450, 2c29 | |
| CYP2C9 | |
| CYPIIC9 | |
| cytochrome P450, subfamily IIC, polypeptide 9 | |
| cytochrome P450, subfamily IIC, polypeptide IX | |
| P450 MP-4 | |
| P-450MP | |
| P450 MP IV | |
| cytochrome P450, family 2, subfamily c, polypeptide 29 | |
| Cyp2c29 | |
| cyp2c7 | |
| cytochrome p450, family 2, subfamily c, polypeptide 7 |
| Organism | Homo sapiens |
|---|---|
| Rattus norvegicus |
| OMIM ID | 601130 |
|---|---|
| 122700 |