| URN | urn:agi-llid:3326 |
|---|---|
| Name | HSP90AB1 |
| Description | heat shock protein 90kDa alpha (cytosolic), class B member 1 |
| Connectivity | 83 |
| Notes | HSP90 proteins are highly conserved molecular chaperones that have key roles in signal transduction, protein folding, protein degradation, and morphologic evolution. HSP90 proteins normally associate with other cochaperones and play important roles in folding newly synthesized proteins or stabilizing and refolding denatured proteins after stress. There are 2 major cytosolic HSP90 proteins, HSP90AA1 (MIM 140571), an inducible form, and HSP90AB1, a constitutive form. Other HSP90 proteins are found in endoplasmic reticulum (HSP90B1; MIM 191175) and mitochondria (TRAP1; MIM 606219) (Chen et al., 2005 [PubMed 16269234]).[supplied by OMIM] |
| Swiss-Prot Accession | B2R5P0 |
|---|---|
| P08238 | |
| O14942 | |
| Q6PK50 | |
| Q9H6X9 | |
| Q71LX8 | |
| P11499 | |
| Q80YC2 | |
| Q811H6 | |
| P34058 |
| Unigene ID | Hs.509736 |
|---|---|
| Hs.689683 | |
| Mm.2180 | |
| Rn.98667 |
| KEGG ID | hsa:3326 |
|---|---|
| mmu:15516 | |
| rno:301252 |
| Swiss-Prot ID | HS90B_HUMAN |
|---|---|
| HS90B_RAT | |
| B2R5P0_HUMAN | |
| Q71LX8_MOUSE |
| GO ID | 0005524 |
|---|---|
| 0030911 | |
| 0030235 | |
| 0000166 | |
| 0051082 | |
| 0032435 | |
| 0045429 | |
| 0006457 | |
| 0060334 | |
| 0060338 | |
| 0006986 | |
| 0005737 | |
| 0042470 | |
| 0005515 | |
| 0001890 | |
| 0006950 | |
| 0005622 | |
| 0005739 |
| Pathway | VDR Targets |
|---|
| IPI ID | IPI00414676 |
|---|---|
| IPI00411633 | |
| IPI00640129 | |
| IPI00515119 | |
| IPI00746291 | |
| IPI00514027 | |
| IPI00554929 | |
| IPI00229080 | |
| IPI00830562 | |
| IPI00471584 |
| Mouse chromosome position | 17 15.0 cM |
|---|
| GO Molecular Function | protein binding |
|---|---|
| nucleotide binding | |
| ATP binding | |
| unfolded protein binding | |
| TPR domain binding | |
| nitric-oxide synthase regulator activity |
| Homologene ID | 74306 |
|---|
| Hugo ID | 5258 |
|---|
| GO Cellular Component | intracellular |
|---|---|
| cytoplasm | |
| mitochondrion | |
| melanosome |
| MGI ID | 96247 |
|---|
| Human chromosome position | 6p12 |
|---|
| GO Biological Process | negative regulation of proteasomal ubiquitin-dependent protein catabolic process |
|---|---|
| positive regulation of nitric oxide biosynthetic process | |
| regulation of type I interferon-mediated signaling pathway | |
| regulation of interferon-gamma-mediated signaling pathway | |
| protein folding | |
| placenta development | |
| response to stress | |
| response to unfolded protein |
| Rat chromosome position | 9q12 |
|---|
| Group | intracellular |
|---|---|
| cytoplasm | |
| mitochondrion | |
| melanosome | |
| protein binding | |
| nucleotide binding | |
| ATP binding | |
| unfolded protein binding | |
| TPR domain binding | |
| nitric-oxide synthase regulator activity | |
| negative regulation of proteasomal ubiquitin-dependent protein catabolic process | |
| positive regulation of nitric oxide biosynthetic process | |
| regulation of type I interferon-mediated signaling pathway | |
| regulation of interferon-gamma-mediated signaling pathway | |
| protein folding | |
| placenta development | |
| response to stress | |
| response to unfolded protein |
| RGD ID | 1303075 |
|---|
| LocusLink ID | 3326 |
|---|---|
| 15516 | |
| 301252 |
| Alias | HSPC2 |
|---|---|
| HSPCB | |
| D6S182 | |
| HSP90B | |
| FLJ26984 | |
| HSP90-BETA | |
| RP1-302G2.1 | |
| heat shock 90kDa protein 1, beta | |
| OTTHUMP00000016517 | |
| OTTHUMP00000016518 | |
| OTTHUMP00000016519 | |
| OTTHUMP00000039869 | |
| heat shock protein beta | |
| heat shock 90kD protein 1, beta | |
| 90kDa | |
| Hsp84 | |
| Hsp90 | |
| C81438 | |
| Hsp84-1 | |
| AL022974 | |
| MGC115780 | |
| heat shock protein 1, beta | |
| OTTMUSP00000021764 | |
| heat shock protein, 84 kDa 1 | |
| retinal degeneration slow protein | |
| heat shock protein 90kDa alpha (cytosolic), class B member 1 | |
| MGC94263 | |
| heat shock protein 90-beta | |
| Heat shock protein HSP 90-beta | |
| HSP 90-beta | |
| heat shock protein 84 | |
| 90 kDa Heat-shock protein-1, beta | |
| heat shock 90kDa 1, beta | |
| HS9B_HUMAN | |
| HSP80-2 | |
| heat shock protein, 84 kDa I | |
| Hsp84 I | |
| HS9B | |
| HSP 84 | |
| LOC115284 | |
| LOC154342 | |
| LOC224806 | |
| HSP90AB1 | |
| C81438s |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 140572 |
|---|