| URN | urn:agi-llid:5337 |
|---|---|
| Name | PLD1 |
| Description | phospholipase D1, phosphatidylcholine-specific |
| Connectivity | 242 |
| Notes | Phosphatidylcholine (PC)-specific phospholipases D (PLDs; EC 3.1.4.4) catalyze the hydrolysis of PC to produce phosphatidic acid and choline. A range of agonists acting through G protein-coupled receptors and receptor tyrosine kinases stimulate this hydrolysis. PC-specific PLD activity has been implicated in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis (Hammond et al., 1995 [PubMed 8530346]).[supplied by OMIM] |
| Swiss-Prot Accession | Q59EA4 |
|---|---|
| Q13393 | |
| Q6NVF2 | |
| Q3UWT7 | |
| Q9Z280 | |
| P70496 |
| Unigene ID | Hs.382865 |
|---|---|
| Mm.212039 | |
| Rn.11130 |
| KEGG ID | hsa:5337 |
|---|---|
| rno:25096 |
| EC Number | 3.1.4.4 |
|---|
| Swiss-Prot ID | PLD1_HUMAN |
|---|---|
| PLD1_RAT | |
| Q59EA4_HUMAN | |
| Q6NVF2_MOUSE |
| Cell Localization | Plasma membrane |
|---|
| GO ID | 0070290 |
|---|---|
| 0016787 | |
| 0035091 | |
| 0004630 | |
| 0005515 | |
| 0007265 | |
| 0007154 | |
| 0006935 | |
| 0016042 | |
| 0008152 | |
| 0005794 | |
| 0000139 | |
| 0005737 | |
| 0005783 | |
| 0005789 | |
| 0005768 | |
| 0031902 | |
| 0016020 | |
| 0003824 | |
| 0050830 | |
| 0006654 | |
| 0008654 | |
| 0009395 | |
| 0030335 | |
| 0043434 | |
| 0031985 | |
| 0030027 | |
| 0005792 | |
| 0031982 |
| Pathway | VDR Targets |
|---|
| IPI ID | IPI00012865 |
|---|---|
| IPI00218797 | |
| IPI00218798 | |
| IPI00218799 | |
| IPI00791503 | |
| IPI00793302 | |
| IPI00790110 | |
| IPI00130629 | |
| IPI00229888 | |
| IPI00421083 | |
| IPI00881282 | |
| IPI00880456 | |
| IPI00881154 | |
| IPI00231170 | |
| IPI00188898 | |
| IPI00231169 |
| Ariadne Ontology | Lipid degradation |
|---|
| Mouse chromosome position | 3 10.5 cM |
|---|
| GO Molecular Function | catalytic activity |
|---|---|
| protein binding | |
| phosphoinositide binding | |
| hydrolase activity | |
| NAPE-specific phospholipase D activity | |
| phospholipase D activity |
| Homologene ID | 116234 |
|---|
| Hugo ID | 9067 |
|---|
| GO Cellular Component | membrane |
|---|---|
| microsome | |
| lamellipodium | |
| Golgi membrane | |
| endoplasmic reticulum membrane | |
| cytoplasm | |
| endosome | |
| Golgi apparatus | |
| endoplasmic reticulum | |
| late endosome membrane | |
| Golgi cisterna | |
| vesicle |
| MGI ID | 109585 |
|---|
| Human chromosome position | 3q26 |
|---|
| GO Biological Process | metabolic process |
|---|---|
| positive regulation of cell migration | |
| Ras protein signal transduction | |
| cell communication | |
| phospholipid biosynthetic process | |
| phosphatidic acid biosynthetic process | |
| phospholipid catabolic process | |
| chemotaxis | |
| lipid catabolic process | |
| defense response to Gram-positive bacterium | |
| response to peptide hormone stimulus |
| Rat chromosome position | 2q23.3-q24 |
|---|
| Group | Lipid degradation |
|---|---|
| membrane | |
| microsome | |
| lamellipodium | |
| Golgi membrane | |
| endoplasmic reticulum membrane | |
| cytoplasm | |
| endosome | |
| Golgi apparatus | |
| endoplasmic reticulum | |
| late endosome membrane | |
| Golgi cisterna | |
| vesicle | |
| catalytic activity | |
| protein binding | |
| phosphoinositide binding | |
| hydrolase activity | |
| NAPE-specific phospholipase D activity | |
| phospholipase D activity | |
| metabolic process | |
| positive regulation of cell migration | |
| Ras protein signal transduction | |
| cell communication | |
| phospholipid biosynthetic process | |
| phosphatidic acid biosynthetic process | |
| phospholipid catabolic process | |
| chemotaxis | |
| lipid catabolic process | |
| defense response to Gram-positive bacterium | |
| response to peptide hormone stimulus |
| RGD ID | 3349 |
|---|
| LocusLink ID | 5337 |
|---|---|
| 18805 | |
| 25096 |
| Alias | phospholipase D1, phophatidylcholine-specific |
|---|---|
| choline phosphatase 1 | |
| Pld1a | |
| Pld1b | |
| C85393 | |
| AA536939 | |
| phospholipase D1 | |
| Plda | |
| Pldb | |
| Phoshpolipase D gene 1 probably with two splicing variants A and B | |
| phospholipase D gene 1, probably with two splicing variants A and B | |
| Phoshpolipase D gene 1 | |
| Phoshpolipase D gene I | |
| Phosphatidylcholine-hydrolyzing phospholipase D1 | |
| PLD1 | |
| phospholipase D1, phosphatidylcholine-specific | |
| LOC229153 | |
| hPLD1 | |
| Choline phosphatase I | |
| PLD I | |
| hPLD I | |
| C85393s |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 602382 |
|---|