| URN | urn:agi-llid:5245 |
|---|---|
| Name | PHB |
| Description | prohibitin |
| Connectivity | 119 |
| Notes | Prohibitin is an evolutionarily conserved gene that is ubiquitously expressed. It is thought to be a negative regulator of cell proliferation and may be a tumor suppressor. Mutations in PHB have been linked to sporadic breast cancer. Prohibitin is expressed as two transcripts with varying lengths of 3' untranslated region. The longer transcript is present at higher levels in proliferating tissues and cells, suggesting that this longer 3' untranslated region may function as a trans-acting regulatory RNA. [provided by RefSeq] |
| Swiss-Prot Accession | A8K401 |
|---|---|
| P35232 | |
| Q13022 | |
| Q53FV0 | |
| Q6FHP5 | |
| Q6PUJ7 | |
| P67778 | |
| Q3TV00 | |
| Q5SQG5 |
| Unigene ID | Hs.514303 |
|---|---|
| Mm.263862 | |
| Rn.29754 |
| KEGG ID | hsa:5245 |
|---|---|
| mmu:18673 | |
| rno:688815 |
| Swiss-Prot ID | PHB_HUMAN |
|---|---|
| PHB_MOUSE | |
| A8K401_HUMAN |
| GO ID | 0005515 |
|---|---|
| 0016563 | |
| 0016564 | |
| 0006260 | |
| 0016575 | |
| 0008285 | |
| 0016481 | |
| 0042981 | |
| 0007165 | |
| 0005887 | |
| 0016020 | |
| 0005743 | |
| 0005739 | |
| 0005654 | |
| 0005634 |
| Pathway | VDR Targets |
|---|
| IPI ID | IPI00017334 |
|---|---|
| IPI00816719 | |
| IPI00791634 | |
| IPI00793658 | |
| IPI00793442 | |
| IPI00133440 | |
| IPI00876224 | |
| IPI00649084 | |
| IPI00559336 |
| Mouse chromosome position | 11 55.6 cM |
|---|
| GO Molecular Function | protein binding |
|---|---|
| transcription activator activity | |
| transcription repressor activity |
| Homologene ID | 1980 |
|---|
| Hugo ID | 8912 |
|---|
| GO Cellular Component | membrane |
|---|---|
| mitochondrion | |
| mitochondrial inner membrane | |
| nucleus | |
| nucleoplasm | |
| integral to plasma membrane |
| MGI ID | 97572 |
|---|
| Human chromosome position | 17q21 |
|---|
| GO Biological Process | negative regulation of cell proliferation |
|---|---|
| negative regulation of transcription | |
| signal transduction | |
| regulation of apoptosis | |
| histone deacetylation | |
| DNA replication |
| Rat chromosome position | 19p13 |
|---|
| Group | membrane |
|---|---|
| mitochondrion | |
| mitochondrial inner membrane | |
| nucleus | |
| nucleoplasm | |
| integral to plasma membrane | |
| protein binding | |
| transcription activator activity | |
| transcription repressor activity | |
| negative regulation of cell proliferation | |
| negative regulation of transcription | |
| signal transduction | |
| regulation of apoptosis | |
| histone deacetylation | |
| DNA replication |
| RGD ID | 1584151 |
|---|
| LocusLink ID | 5245 |
|---|---|
| 18673 | |
| 688815 |
| Alias | PHB1 |
|---|---|
| prohibitin | |
| BAP32 | |
| RP23-17C2.2 | |
| OTTMUSP00000001681 | |
| similar to prohibitin | |
| A-kinase anchoring AKAP 220 | |
| Phb | |
| LOC682174 | |
| LOC688815 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 176705 |
|---|