| URN | urn:agi-llid:8714 |
|---|---|
| Name | ABCC3 |
| Description | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 |
| Connectivity | 80 |
| Notes | The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in the transport of biliary and intestinal excretion of organic anions. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq] |
| Swiss-Prot Accession | B2RPA9 |
|---|---|
| O15438 | |
| Q2M3C9 | |
| Q59H05 | |
| Q86VN9 | |
| Q86X85 | |
| Q96QA9 | |
| B2RX12 | |
| Q59DK8 | |
| Q9CVX4 | |
| O88563 | |
| Q923G8 |
| Unigene ID | Hs.463421 |
|---|---|
| Mm.23942 | |
| Rn.205054 |
| KEGG ID | hsa:8714 |
|---|---|
| rno:140668 |
| Swiss-Prot ID | MRP3_HUMAN |
|---|---|
| MRP3_MOUSE | |
| MRP3_RAT | |
| B2RPA9_HUMAN | |
| Q86X85_HUMAN |
| Cell Localization | Plasma membrane |
|---|
| GO ID | 0005524 |
|---|---|
| 0016887 | |
| 0042626 | |
| 0000166 | |
| 0008514 | |
| 0005215 | |
| 0015722 | |
| 0006810 | |
| 0005887 | |
| 0016020 | |
| 0005624 | |
| 0017111 | |
| 0016021 | |
| 0015432 | |
| 0015238 | |
| 0008559 | |
| 0015893 | |
| 0006855 | |
| 0032355 | |
| 0032496 | |
| 0014070 | |
| 0010243 | |
| 0010033 | |
| 0016323 |
| Pathway | Toxicology Array |
|---|---|
| VDR Targets |
| IPI ID | IPI00006674 |
|---|---|
| IPI00251066 | |
| IPI00219843 | |
| IPI00219844 | |
| IPI00797470 | |
| IPI00330966 | |
| IPI00874883 | |
| IPI00915521 | |
| IPI00568685 | |
| IPI00231499 |
| Ariadne Ontology | OA transport |
|---|
| Mouse chromosome position | 11 D |
|---|
| GO Molecular Function | transporter activity |
|---|---|
| nucleotide binding | |
| ATP binding | |
| ATPase activity, coupled to transmembrane movement of substances | |
| xenobiotic-transporting ATPase activity | |
| bile acid-exporting ATPase activity | |
| nucleoside-triphosphatase activity | |
| ATPase activity | |
| drug transporter activity | |
| organic anion transmembrane transporter activity |
| Homologene ID | 68364 |
|---|
| Hugo ID | 54 |
|---|
| GO Cellular Component | membrane |
|---|---|
| membrane fraction | |
| integral to membrane | |
| integral to plasma membrane | |
| basolateral plasma membrane |
| MGI ID | 1923658 |
|---|
| Human chromosome position | 17q22 |
|---|
| GO Biological Process | multidrug transport |
|---|---|
| transport | |
| drug transport | |
| canalicular bile acid transport | |
| response to lipopolysaccharide | |
| response to organic substance | |
| response to estradiol stimulus | |
| response to organic nitrogen | |
| response to organic cyclic substance |
| Rat chromosome position | 10q26 |
|---|
| Group | OA transport |
|---|---|
| membrane | |
| membrane fraction | |
| integral to membrane | |
| integral to plasma membrane | |
| basolateral plasma membrane | |
| transporter activity | |
| nucleotide binding | |
| ATP binding | |
| ATPase activity, coupled to transmembrane movement of substances | |
| xenobiotic-transporting ATPase activity | |
| bile acid-exporting ATPase activity | |
| nucleoside-triphosphatase activity | |
| ATPase activity | |
| drug transporter activity | |
| organic anion transmembrane transporter activity | |
| multidrug transport | |
| transport | |
| drug transport | |
| canalicular bile acid transport | |
| response to lipopolysaccharide | |
| response to organic substance | |
| response to estradiol stimulus | |
| response to organic nitrogen | |
| response to organic cyclic substance |
| RGD ID | 71101 |
|---|
| LocusLink ID | 8714 |
|---|---|
| 76408 | |
| 140668 |
| Alias | MLP2 |
|---|---|
| MRP3 | |
| ABC31 | |
| MOAT-D | |
| cMOAT2 | |
| EST90757 | |
| DKFZp686E22157 | |
| ATP-binding cassette, sub-family C, member 3 | |
| multidrug resistance associated protein | |
| canicular multispecific organic anion transporter | |
| 1700019L09Rik | |
| RP23-65I14.2 | |
| ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | |
| transporter | |
| OTTMUSP00000001838 | |
| ATP-binding cassette protein C3 | |
| ATP-binding cassette transporter | |
| multidrug resistance-associated protein 3 | |
| organic anion transporter | |
| multidrug resistance protein 3 | |
| Abcc3 | |
| ATP-binding cassette, sub-family C, member 3 MRP3B | |
| ATP-binding cassette, sub-family C, member 3 MRP3 | |
| ATP-binding cassette, sub-family C, member 3 MRP3A | |
| ATP-binding cassette, sub-family C (CFTR/MRP), member III | |
| Multidrug resistance-associated protein III | |
| Multidrug resistance-associated protein 3 | |
| atp-binding cassette, sub-family c, member III | |
| atp-binding cassette, sub-family c (cftr\/mrp), member 3 | |
| atp-binding cassette, sub-family c (cftr\/mrp), member III | |
| mrp3b | |
| mrp3a | |
| Canalicular multispecific organic anion transporter 2 | |
| Canalicular multispecific organic anion transporter II | |
| CMOAT2s |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 604323 |
|---|