| URN | urn:agi-llid:8074 |
|---|---|
| Name | FGF23 |
| Description | fibroblast growth factor 23 |
| Connectivity | 107 |
| Notes | The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The product of this gene inhibits renal tubular phosphate transport. This gene was identified by its mutations associated with autosomal dominant hypophosphatemic rickets (ADHR), an inherited phosphate wasting disorder. Abnormally high level expression of this gene was found in oncogenic hypophosphatemic osteomalacia (OHO), a phenotypically similar disease caused by abnormal phosphate metabolism. Mutations in this gene have also been shown to cause familial tumoral calcinosis with hyperphosphatemia. [provided by RefSeq] |
| Swiss-Prot Accession | Q9GZV9 |
|---|---|
| Q7Z4T2 | |
| Q3U1V5 | |
| Q9EPC2 | |
| Q0VBJ8 | |
| Q8VI82 |
| Unigene ID | Hs.287370 |
|---|---|
| Mm.347933 | |
| Rn.154421 |
| KEGG ID | hsa:8074 |
|---|---|
| rno:170583 |
| Swiss-Prot ID | Q3U1V5_MOUSE |
|---|---|
| FGF23_MOUSE | |
| FGF23_HUMAN | |
| FGF23_RAT |
| Cell Localization | Extracellular |
|---|
| GO ID | 0008083 |
|---|---|
| 0030154 | |
| 0030643 | |
| 0008543 | |
| 0030500 | |
| 0005576 | |
| 0005615 | |
| 0005104 | |
| 0006796 | |
| 0042359 | |
| 0044421 |
| Pathway | FGFR3 -> STAT signaling |
|---|---|
| FGFR -> RUNX2 signaling | |
| VDR Targets |
| IPI ID | IPI00026407 |
|---|---|
| IPI00109761 | |
| IPI00207491 |
| Ariadne Ontology | GF |
|---|
| Mouse chromosome position | 6 F3 |
|---|
| GO Molecular Function | growth factor activity |
|---|---|
| fibroblast growth factor receptor binding |
| Homologene ID | 10771 |
|---|
| Hugo ID | 3680 |
|---|
| GO Cellular Component | extracellular region |
|---|---|
| extracellular region part | |
| extracellular space |
| MGI ID | 1891427 |
|---|
| Human chromosome position | 12p13.3 |
|---|
| GO Biological Process | fibroblast growth factor receptor signaling pathway |
|---|---|
| regulation of bone mineralization | |
| cellular phosphate ion homeostasis | |
| cell differentiation | |
| phosphate metabolic process | |
| vitamin D metabolic process |
| Rat chromosome position | 4q42 |
|---|
| Group | GF |
|---|---|
| extracellular region | |
| extracellular region part | |
| extracellular space | |
| growth factor activity | |
| fibroblast growth factor receptor binding | |
| fibroblast growth factor receptor signaling pathway | |
| regulation of bone mineralization | |
| cellular phosphate ion homeostasis | |
| cell differentiation | |
| phosphate metabolic process | |
| vitamin D metabolic process |
| RGD ID | 620178 |
|---|
| LocusLink ID | 8074 |
|---|---|
| 64654 | |
| 170583 |
| Alias | ADHR |
|---|---|
| HYPF | |
| HPDR2 | |
| PHPTC | |
| fibroblast growth factor 23 | |
| tumor-derived hypophosphatemia inducing factor | |
| FGF-23 | |
| Hypophosphatemia vitamin D-resistant rickets-2 | |
| Hypophosphatemia vitamin D-resistant rickets-2 (autosomal dominant) | |
| Hypophosphatemia vitamin D-resistant rickets II | |
| tumor-derived hypophophatemia inducing factor | |
| FGF23 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 605380 |
|---|---|
| 211900 | |
| 193100 |