| URN | urn:agi-llid:2826 |
|---|---|
| Name | CCR10 |
| Description | chemokine (C-C motif) receptor 10 |
| Connectivity | 46 |
| Notes | Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines. CCR10 is the receptor for CCL27 (SCYA27; MIM 604833); CCR10-CCL27 interactions are involved in T cell-mediated skin inflammation (Homey et al., 2002 [PubMed 11821900]).[supplied by OMIM] |
| Swiss-Prot Accession | P46092 |
|---|---|
| Q542A4 | |
| Q9JL21 |
| Unigene ID | Hs.278446 |
|---|---|
| Mm.8021 | |
| Rn.49607 |
| KEGG ID | hsa:2826 |
|---|---|
| mmu:12777 | |
| rno:363682 |
| Swiss-Prot ID | CCR10_HUMAN |
|---|---|
| Q542A4_MOUSE |
| Cell Localization | Plasma membrane |
|---|
| GO ID | 0016493 |
|---|---|
| 0004930 | |
| 0005515 | |
| 0004872 | |
| 0007186 | |
| 0006935 | |
| 0007204 | |
| 0007165 | |
| 0005887 | |
| 0005886 | |
| 0004950 | |
| 0004871 | |
| 0016021 | |
| 0016020 |
| Pathway | VDR Targets |
|---|
| IPI ID | IPI00004346 |
|---|---|
| IPI00311600 | |
| IPI00606841 | |
| IPI00368108 |
| Ariadne Ontology | GPCR-GiCR |
|---|
| Mouse chromosome position | 11 59.0 cM |
|---|
| GO Molecular Function | protein binding |
|---|---|
| chemokine receptor activity | |
| C-C chemokine receptor activity | |
| signal transducer activity | |
| receptor activity | |
| G-protein coupled receptor activity |
| Homologene ID | 7271 |
|---|
| Hugo ID | 4474 |
|---|
| GO Cellular Component | membrane |
|---|---|
| plasma membrane | |
| integral to membrane | |
| integral to plasma membrane |
| MGI ID | 1096320 |
|---|
| Human chromosome position | 17q21.1-q21.3 |
|---|
| GO Biological Process | signal transduction |
|---|---|
| G-protein coupled receptor protein signaling pathway | |
| elevation of cytosolic calcium ion concentration | |
| chemotaxis |
| Rat chromosome position | 10q32.1 |
|---|
| Group | GPCR-GiCR |
|---|---|
| membrane | |
| plasma membrane | |
| integral to membrane | |
| integral to plasma membrane | |
| protein binding | |
| chemokine receptor activity | |
| C-C chemokine receptor activity | |
| signal transducer activity | |
| receptor activity | |
| G-protein coupled receptor activity | |
| signal transduction | |
| G-protein coupled receptor protein signaling pathway | |
| elevation of cytosolic calcium ion concentration | |
| chemotaxis |
| RGD ID | 1310716 |
|---|
| LocusLink ID | 2826 |
|---|---|
| 12777 | |
| 363682 |
| Alias | GPR2 |
|---|---|
| CC chemokine receptor 10 | |
| G protein-coupled receptor 2 | |
| Cmkbr9 | |
| MGC151420 | |
| RP23-281C18.3 | |
| chemokine (C-C motif) receptor 10 | |
| OTTMUSP00000002576 | |
| C-C CKR-10 | |
| CCR-10 | |
| CKRA | |
| CKRA_HUMAN | |
| CC-CKR-10 | |
| C-C chemokine receptor type 10 | |
| C-C CKR X | |
| CCR X | |
| CC-CKR X | |
| CCR10 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 600240 |
|---|